| 王书书,潘家华.40例儿童紫癜肾临床资料分析[J].安徽医药,2017,21(8):1429-1431. |
| 40例儿童紫癜肾临床资料分析 |
| Clinial analysis of 40 children with Henoch-Schnlein purpura nephritis |
| 投稿时间：2017-02-19 |
| DOI： |
| 中文关键词: 过敏性紫癜 紫癜肾 危险因素 |
| 英文关键词: Henoch-Schnlein purpura Henoch-Schnlein purpura nephritis Risk factors |
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| 中文摘要: |
| 目的 探讨影响过敏性紫癜肾损害的危险因素。方法 2013年1月—2016年6月收住安徽省立医院的过敏性紫癜肾患儿40例,以同期收住病房的56例过敏性紫癜患儿不合并肾损害的为对照组,进行肾损害的单因素分析及Logistic多元回归分析。结果 过敏性紫癜患儿出现肾损害时距离第一次出现皮肤紫癜平均(4.46±1.28)周,首发表现以单纯血尿患儿最多,为15例(37.5%)；过敏性紫癜肾患儿的平均血小板体积、嗜酸粒细胞绝对值、中性粒细胞/淋巴细胞比值与无肾损害患儿相比明显增加,差异有统计学意义(P<0.05),且皮疹反复发生>2周的患儿肾损害的发生率高于无肾损害患儿。结论 平均血小板体积增大、嗜酸粒细胞增多、中性粒细胞/淋巴细胞比值增加,皮疹反复发生>2周是过敏性紫癜肾损害发生的危险因素,提示临床医生应高度重视,对具有上述危险因素的过敏性紫癜患儿需密切监测尿常规、尿微量白蛋白、胱抑素C水平,及早发现肾损害,制定相应治疗方案,提高患儿远期预后。 |
| 英文摘要: |
| To explore risk factors for Henoch-Schnlein purpura nephritis. Methods 40 children with Henoch-Schnlein purpura nephritis admitted to pediatric department ofAnhui provincial hospital between January 2013 and June 2016 were selected as the observation group while 56 children in the same period with Henoch-Schnlein purpura without renal damage for the control group.Single factor of renal damage and multi-factor Logistic analysis were conducted. Results The average time that Henoch-Schnlein purpur anephritis happened was(4.46±1.28) weeks since the first appearance of skin purpura.The most frequent performance of nephritis was isolated hematuria due to the fact that 15 patients(37.5%)were taken on isolated hematuria.Mean platelet volume,the number of eosinophile granulocyte,neutrophils/lymphocyte ratio were increased when compared with the control group(P<0.05).Patients with repeated rash more than 2 weeks got a higher incidence of renal damage. Conclusion Increase of mean platelet volume,the number of eosinophile granulocyte and neutrophils/lymphocyte ratio as well as repeated rash more than 2 weeks were the risk factors of Henoch-Schnlein purpura nephritis.Peditricians should pay more attention and monitor the routine urinalysis,urine trace albumin,the level of cystatin Cin order to suspect information of early renal damage,followed by drafting corresponding treatment immediately. |
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