| 郭萍,周秀娟,郭艳如,等.戊巴比妥钠腹腔麻醉对C57BL/6J小鼠体表心电图的影响[J].安徽医药,2017,21(11):1979-1982. |
| 戊巴比妥钠腹腔麻醉对C57BL/6J小鼠体表心电图的影响 |
| Drug-induced effects on the electrocardiogram during intraperitoneal anesthesia with pentobarbital sodium:study in C57BL/6J mice |
| 投稿时间：2017-03-29 |
| DOI： |
| 中文关键词: 戊巴比妥钠 麻醉 小鼠 心电图 |
| 英文关键词: Sodium pentobarbital Anesthesia Mice Electrocardiogram |
| 基金项目:国家自然科学基金面上项目(81170161,81070158) |
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| 中文摘要: |
| 目的 观察戊巴比妥钠腹腔内注射麻醉对小鼠体表心电图(ECG)指标,包括心率、PR间期、QRS波宽度和QT间期随麻醉时间延长的变化规律。方法 6只雄性C57BL/6J小鼠,腹腔内注射戊巴比妥钠75 mg·kg-1后,每10 min记录ECG一次,直至90 min,分析ECG各指标的变化规律。结果 所有6只小鼠均顺利完成实验。戊巴比妥钠腹腔内注射后10～60 min时随给药时间延长,测得的心率显著减慢[(353.0±31.3)、(287.5±34.8)、(234.9±38)、(207.9±37.3)、(190.8±32.9)和(175.8±25.5)次/分钟,P<0.01],QRS波宽度显著增宽[(11.3±0.5)、(12.3±0.5)、(13.3±0.7)、(13.9±0.8)、(14.1±0.9)和(14.3±1.0)ms,P<0.05],QT间期显著延长[(18.8±0.5)、(20.9±0.9)、(23.0±1.1)、(24.5±1.3)、(25.7±2.0)和(26.4±2.2)ms,P<0.05]。给药后60～90 min内测得的心率、QRS波宽度及QT间期均随给药时间延长而改变轻微,趋于平稳。而PR间期在注射后10～90 min的相邻两个测量采集点比较,均随给药时间延长而显著延长。结论 戊巴比妥钠腹腔注射麻醉可致小鼠心率显著减慢,PR间期、QRS波宽度和QT间期等ECG指标随麻醉时间延长而明显延长,在研究心律失常模式动物心电学表型时应予以重视。 |
| 英文摘要: |
| Objective To investigate the effects of sodium pentobarbital on the surface ECG parameters,including heart rate (HR),PR interval,QRS duration,and QT interval in C57BL/6J mice. Methods A total of 6 male mice (C57BL/6J,aged 10 weeks,weighed 23.6±1.3 g) were included in the present study.After intraperitoneal injection of sodium pentobarbital (75 mg·kg-1),ECGs parameters were recorded every 10 minutes (10,0,30,0,50,0,70,0,90 minutes) by utilizing LabChart software of the Powerlab recording system. Results The prolonged time (from 10 minutes to 60 minutes) of sodium pentobarbital administration had a significant effect on decreased HR(353.0±31.3),(287.5±34.8),(234.9±38),(207.9±37.3),(190.8±32.9) and(175.8±25.5) bpm,respectively,P<0.05),prolonged PR interval(38.3±3.0),(42.8±2.4),(48.3±3.1),(50.5±3.57),(53.1±3.6) and(55.7±4.1) ms,respectively,P<0.05),prolonged QRS duration(11.3±0.5),(12.3±0.5),(13.3±0.7),(13.9±0.8),(14.1±0.9) and(14.3±1.0) ms,respectively,P<0.05),and prolonged QT interval(18.8±0.5),(20.9±0.9),(23.0±1.1),(24.5±1.3),(25.7±2.0) and(26.4±2.2) ms,respectively,P<0.05).However,these indicators,such as HR,QRS duration,and QT interval,have no significant changesfrom 60 to 90 minutes except the prolonged PR interval(55.7±4.1),(57.4±4.5),(58.8±4.6),(60.6±4.9) ms,respectively,P<0.05). Conclusions The prolonged PR interval,QRS duration and QT interval and the shortened HR of C57BL/6J mice after pentobarbital-anesthetized treatment,which should be attached enough attention to the future researches based on model animals of arrhythmia. |
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