| 刘后存.探讨维生素D水平在哮喘儿童吸入皮质激素治疗中的意义[J].安徽医药,2017,21(12):2260-2261. |
| 探讨维生素D水平在哮喘儿童吸入皮质激素治疗中的意义 |
| Effect of vitamin Don asthma children treatment with inhaled corticosteroids |
| 投稿时间：2016-09-04 |
| DOI： |
| 中文关键词: 维生素D 哮喘儿童 吸入激素治疗 |
| 英文关键词: Vitamin D Asthma children Inhaled corticosteroids |
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| 中文摘要: |
| 目的 探讨维生素D水平在哮喘儿童吸入皮质激素治疗中的意义。方法 选择100例哮喘患儿进行研究。所有患儿均进行血清维生素D水平的检测,根据维生素D水平将其分为维生素D缺乏组(维生素D水平＜20 μg·L-1)共10例、维生素D不足组(维生素D水平在20～30 μg·L-1之间)共25例以及维生素D充足组(维生素D水平＞30 μg·L-1)共65例。所有患儿均给予布地奈德气雾剂的吸入,每次200 μg,每天2次。检测各组患儿治疗前和治疗8个月后进行一秒用力呼气容积(FEV1)以及用药后FEV1的改善率。 结果 维生素D缺乏组、不足组和充足组用药前FEV1和用药8个月后FEV1改善率整体比较差异有统计学意义(P<0.05)；多重比较得出维生素D不足组与充足组FEV1之间差异无统计学意义(P>0.05),而缺乏组则与充足组患儿相比差异有统计学意义(P<0.05)。结论 充足的维生素D水平对于哮喘患儿吸入激素治疗提升肺功能起到重要的作用。检测维生素D水平以及维生素D的补充可作为临床上吸入糖皮质激素治疗患儿的参考指标。 |
| 英文摘要: |
| Objective To evaluate the effect of vitamin Dlevels on asthma children treatment with inhaled corticosteroids.Methods One hundred children with asthma were collected in this study.Among them,10 patients had deficient vitamin Dlevels (<20 μg·L-1),25 children were proved to have insufficient vitamin Dlevels (20 to 30 μg·L-1) and 65 cases had sufficient vitamin Dlevels (＞30 μg·L-1).All children were treated with inhaled budesonide,each 200 μg,twice every day.Pre-bronchodilator FEV1 and the change of FEV1 were measured 8 months after treatment.Results There were significant differences in pre-bronchodilator FEV1 and FEV1 improvement rate at 8 months after treatment among vitamin Dsufficiency,insufficiency,or deficiency group (P<0.05).In addition,multiple comparisons showed that the change of FEV1 was not significantly different between vitamin Dinsufficiency group and deficiency group (P>0.05).However,there was significant difference in FEV1 change between vitamin Ddeficiency group and sufficiency group (P<0.05).Conclusions Vitamin Dsufficiency in children treated with inhaled budesonide is associated with improved lung function.Monitoring vitamin Dlevels and supplementing with vitamin Dcould be considered during inhaled budesonide treatment for asthma children. |
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