| 黄大鹏,李倩.急性百草枯中毒临床治疗现状及研究进展[J].安徽医药,2018,22(1):29-32. |
| 急性百草枯中毒临床治疗现状及研究进展 |
| Research progress and clinical treatment of acute paraquatpoisoning |
| 投稿时间：2016-11-08 |
| DOI： |
| 中文关键词: 百草枯中毒 肺纤维化 环磷酰胺 地塞米松 甲强龙 |
| 英文关键词: paraquat poisoning pulmonary fibrosis cytoxan dexamethasone methylprednisolone |
| 基金项目: |
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| 摘要点击次数: 2894 |
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| 中文摘要: |
| 百草枯(PQ)中毒目前已成为急诊科常见的中毒症之一,临床上病死率高达70%以上。PQ可导致全身多个器官损害,尤其以肺出现进行性纤维化为常见死亡原因,其损伤机制尚不明确且临床尚无特效治疗药物,目前主要采取联合治疗的方式予以对症治疗。治疗方式包括早期洗胃、抗自由基联合免疫药物、干细胞移植等。研究发现有效的综合治疗能使部分口服致死量患者存活,但PQ的致死率仍然很高,故需对PQ中毒的治疗进一步探究。 |
| 英文摘要: |
| Paraquat(PQ) poisoninghas become one of the most common poisoning in emergency department,the mortality of which has seen to be more than 70%.PQ can lead to multiple organ damage,especially progressive fibrosis of lungs,which is the common cause of death.The injury mechanism hasn′t been clear and no effective medicines are available in clinics.Therefore,the main therapy is combined treatment,which includes early gastric lavage,anti-free radical immune drugs,and stem cell transplantation.Studies have found that effective comprehensive treatment will help some patients who take lethal oral doses survive.However,the lethality of PQ is stillhigh,the treatment of which needs to be further researched. |
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