| 李璇,刘红建,旷南岳.2012—2016年某三甲医院807例药品不良反应报告分析[J].安徽医药,2018,22(2):285. |
| 2012—2016年某三甲医院807例药品不良反应报告分析 |
| Report analysis of 807 patients with ADR in a three Ahospital during 2012—2016 |
| 投稿时间：2017-02-17 |
| DOI： |
| 中文关键词: 药品不良反应 监测 合理用药 |
| 英文关键词: adverse drug reaction monitor rational drug use |
| 基金项目: |
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| 中文摘要: |
| 目的 分析某三甲医院药品不良反应(ADR)报告的临床特点、规律和相关因素,提高ADR的监测和临床合理用药的水平。 方法 回顾性统计和分析某院2012年—2016年807例ADR报告。 结果 807份ADR报告中,男性患者352例,女性患者455例；60岁以上老年患者ADR构成比较高,占52.8%；静脉滴注为主要给药途径,占74.29%；引起ADR频次较高的药物分别为抗感染药物(占比25.77%)、中成药(占比15.69%)；引起ADR前10位药品的剂型大部分为注射剂,ADR报告中最多的药品是盐酸左氧氟沙星注射液；ADR临床表现以皮肤及其附件损害最常见,其次是全身性损害。 结论 临床应加强ADR的报告和监测工作,应注意老年患者用药安全性,尽可能减少静脉用药,合理使用抗感染药物,慎用中成药制剂,促进临床合理用药,保障患者用药安全。 |
| 英文摘要: |
| Objective To analyze the clinical characteristics,rules and related factors of Adverse Drug Reactions (ADRs) in a three Ahospital,to raise the standards both in ADR monitor and rational drug use. Method By retrospective statistics and analysis of 807 ADR cases in our hospital during 2012—2016. Results Among 807 cases of ADR reports,there were 352 cases of male,455 cases of female.Most of ADR cases occurred in patients over 60 (52.8%).Intravenous infusion is the main administration route (74.29%).25.77% were induced by the anti-infective agents and 15.69 % were Chinese patent medicine.Injection occupied the majority of top 10 drugs inducing ADR,among which Levofloxacin hydrochloride injection was the lead as reported.the clinical manifestation was the most commonly showed as lesion of skin and its appendants injury,and the systematic damage placed the next. Conclusions In order to ensure the rational clinical therapy,clinicians and clinical pharmacists should enhance the report and monitor of ADRs,pay attention to the elderly patients,reduce intravenous drugs.And rational use of anti-infective agents and Chinese patent medicine should be taken into consideration. |
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