| 陈山.雾化吸入阿米卡星对老年呼吸机相关性肺炎血气指标和炎性因子的影响[J].安徽医药,2018,22(5):965-967. |
| 雾化吸入阿米卡星对老年呼吸机相关性肺炎血气指标和炎性因子的影响 |
| Clinical efficacy of aerosol inhalation of Amikacin in the treatment of elderly patients with ventilator-associated pneumonia and its effects on blood gas indexes and inflammatory factors |
| 投稿时间：2016-08-04 |
| DOI： |
| 中文关键词: 阿米卡星 雾化吸入 老年呼吸机相关性肺炎 疗效 |
| 英文关键词: amikacin aerosol inhalation elderly patients with ventilator-associated pneumonia curative effect |
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| 中文摘要: |
| 目的 研究雾化吸入阿米卡星治疗老年呼吸机相关性肺炎(VAP)的临床疗效及对血气指标和炎性因子的影响。 方法选取老年VAP患者110例,按照随机数字表法将患者分为观察组和对照组,每组55例,对照组给予常规治疗,观察组在常规治疗的基础上加用阿米卡星雾化吸入治疗,比较两组临床治愈率、细菌清除率、病死率、血pH值、血氧分压(PaO2)、血二氧化碳分压(PaCO2)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)。 结果 观察组临床治愈率和细菌清除率分别为76.4％、74.5％显著高于对照组的52.7％、41.8％,差异有统计学意义(P＜0.05)；治疗前两组pH值、PaO2以及PaCO2差异无统计学意义(P＞0.05),治疗后两组pH值、PaO2以及PaCO2均明显改善,观察组PaO2和PaCO2显著优于对照组,差异有统计学意义(P＜0.05)；治疗前两组hs-CRP、TNF-α以及IL-6比较,差异无统计学意义(P＞0.05),治疗后两组hs-CRP、TNF-α以及IL-6显著改善,且观察组显著优于对照组,差异有统计学意义(P＜0.05)。 结论 雾化吸入阿米卡星老年VAP疗效显著,能显著改善患者血气指标和炎性因子。 |
| 英文摘要: |
| Objective To study the clinical efficacy of aerosol inhalation of Amikacin in the treatment of elderly patients with ventilator-associated pneumonia (VAP) and its effects on blood gas indexes and inflammatory factors. Methods One hundred and ten cases of elderly patients with VAP were selected and assigned into study group and control group according to the random number table method,55 cases in each group.The control group was given routine treatment,while the study group was treated with Amikacin aerosol inhalation on the basis of conventional treatment.Clinical cure rate,bacterial clearance rate,mortality rate,blood pH,partial pressure of oxygen (PaO2) and blood carbon dioxide partial pressure (PaCO2),high sensitive C-reactive protein (hs-CRP) and tumor necrosis factor alpha (TNF-α),leukocyte mediated IL-6 (IL-6) of two groups were compared. Results The clinical cure rate and bacterial clearance rate of the study group were 76.4% and 74.5%,significantly higher than those of the control group,52.7% and 41.8% respectively.The differences were statistically significant (P<0.05).The pH value,PaO2 and PaCO2 before treatment in the two groups were not significantly different (P>0.05).The pH value,PaO2 and PaCO2 after treatment were significantly improved in the two groups,and the PaO2 and PaCO2 in the study group were significantly better than those in the control group;the differences were statistically significant (P<0.05).The hs-CRP,TNF-α and IL-6 before treatment in two groups were not significantly different (P>0.05).Hs-CRP,TNF-α and IL-6 after treatment were significantly improved in the two groups,and the study group was significantly better than the control group;the differences were statistically significant (P<0.05). Conclusions The effect of aerosol inhalation of Amikacin in the treatment of VAP in elderly patients is significance,which can significantly improve the blood gas indicators and inflammatory factors. |
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