| 吴红杰,陈大忠.锦灯笼宿萼不同提取物对小鼠耐糖量及糖尿病肾病大鼠血糖水平影响[J].安徽医药,2018,22(7):1245-1247. |
| 锦灯笼宿萼不同提取物对小鼠耐糖量及糖尿病肾病大鼠血糖水平影响 |
| Effects of different extracts of Physalis alkekengi L.var.franchetii(Mast.)Makino on blood glucose tolerance in mice and blood glucose level in diabetic nephropathy rats |
| 投稿时间：2017-06-17 |
| DOI： |
| 中文关键词: 锦灯笼 植物提取物 葡糖耐量试验 乙醇 提取法 小鼠 |
| 英文关键词: Physalis alkekengi Plant extracts Glucose tolerance test Ethanol Extraction Mice |
| 基金项目: |
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| 摘要点击次数: 1725 |
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| 中文摘要: |
| 目的 观察锦灯笼宿萼水提取物和乙醇提取物对小鼠耐糖量及对链脲佐菌素(STZ)诱导的糖尿病肾病大鼠血糖的影响。方法 小鼠八组,每组10只,包括蔗糖组4个组和葡萄糖组4个组,蔗糖组分别灌胃给予水提取物1.96 g·kg-1和锦灯笼宿萼70％乙醇提取物1.54 g·kg-1和阿卡波糖,模型组于最后一次给予与实验组等量蔗糖。葡糖糖组分别灌胃给予水提取物1.96 g·kg-1和锦灯笼宿萼70％乙醇提取物1.54 g·kg-1和二甲双胍,模型组于最后一次给予与实验组等量葡萄糖。测定血糖； 对STZ糖尿病肾病模型大鼠分别灌胃给予锦灯笼宿萼70％乙醇提取物0.89 g·kg-1和水提物1.52 g·kg-1,并测定血糖。结果 锦灯笼宿萼不同提取物对小鼠耐糖量影响实验中蔗糖组中70%乙醇提取物组的小鼠0.5 h时血糖值为(8.55±1.35) mmol·L-1,蔗糖模型组小鼠血糖值为(11.04±0.84) mmol·L-1；葡萄糖组中70%乙醇提取物组的小鼠0.5 h时血糖值为(17.92±1.60) mmol·L-1,葡萄糖模型组小鼠血糖值为(21.12±1.60) mmol·L-1；锦灯笼宿萼水提取物组和70%乙醇提取物组与模型组比较,小鼠对蔗糖、葡萄糖的耐糖能力差异有统计学意义(P<0.05)；锦灯笼宿萼不同提取物对 STZ大鼠血糖的影响试验中,锦灯笼宿萼70%乙醇提取物组的血糖值为(32.06±1.52) mmol·L-1,模型组血糖值为(50.53±3.08) mmol·L-1,锦灯笼宿萼70%乙醇提取物组与模型组比较,对降低早期糖尿病肾病的大鼠血糖差异有统计学意义(P<0.05)。结论 锦灯笼宿萼水提物和乙醇提取物能够提高小鼠对蔗糖和葡萄糖的耐糖量,并降低STZ糖尿病肾病大鼠血糖值,乙醇提取部位优于水提取部位。 |
| 英文摘要: |
| Objective To investigate the effect of water extract and 70% ethanol extract of physalis calyx seu fructus persistent calyx on sugar tolerance in mice on and blood glucose in rats with diabetic nephropathy induced by STZ. Methods Eight groups of mice, 10 in each group, were divided into 4 groups of sucrose group and 4 groups of glucose group. Sucrose group give water extract 1.96 g·kg-1 and physalis calyx seu fructus persistent calyx 70% ethanol extract 1.54 g·kg-1 and acarbose by intragastric administration respectively,the model group was given the same amount of sucrose as the experimental group in the last, glucose group give water extract 1.96 g·kg-1 and physalis calyx seu fructus persistent calyx 70% ethanol extract 1.54 g·kg-1 and metformin by intragastric administration respectively, the model group was given the same amount of glucose as the experimental group for the last time and the blood glucose of mouse were determined; Rats with diabetic nephropathy induced by STZ were given intragastric administration of physalis calyx seu fructus persistent calyx of calyx 70% ethanol extract of g·kg-1and water extract of 1.52 g·kg-1, and the blood glucose of rats were determined. Results Effect of different extracts of Physalis calyx seu fructus persistent calyx on the sugar tolerance of mice. The blood glucose values of the mice in the 70% ethanol extract group were (8.55±1.35) mmol·L-1 at 0.5 h, (11.04±0.84) mmol·L-1 in the sucrose model group,(17.92±1.60) mmol·L-1 in the glucose 70% ethanol extract group and (21.12±1.60) mmol·L-1 in the glucose model group at 0.5 h. Compared with the model group, the blood glucose level of the rats of 70% ethanol extract group with early diabetic nephropathy was significantly lower than that of the control group(P<0.05). Effects of different extracts from Physalis calyx seu fructus persistent calyx on the blood glucose in STZ rats,The blood glucose level in the 70% ethanol extract group of Physalis calyx seu fructus persistent calyx was (32.06±1.52) mmol·L-1, and the blood glucose level in the model group was (50.53±3.08) mmol·L-1.Compared with the model group, the blood glucose level of the rats of 70% ethanol extract group with early diabetic nephropathy was significantly lower than that of the control group(P<0.05). Conclusion The extract of water group and 70% ethanol extract group can increase the glucose tolerance factor of sucrose and glucose and decrease the blood glucose level of STZ-induced diabetic nephropathy rats, and the ethanol extraction site is better than water extraction site. |
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