| 匡铭,罗华,郭道宁.开腹射频消融与开腹手术切除治疗小肝癌的临床疗效分析[J].安徽医药,2018,22(7):1357-1359. |
| 开腹射频消融与开腹手术切除治疗小肝癌的临床疗效分析 |
| Analysis of clinical effect of open abdominal radiofrequency ablation and laparotomy in treatment of small hepatocellular carcinomn |
| 投稿时间：2016-11-11 |
| DOI： |
| 中文关键词: 肝肿瘤 导管消融术 肝切除术 丙氨酸转氨酶 胆碱酯酶类 治疗结果 |
| 英文关键词: Liver neoplasms Catheter ablation Hepatectomy Alanine transaminase Cholinesterases Treatment outcome |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨开腹射频消融与开腹手术切除治疗小肝癌的临床疗效以及安全性。方法 回顾性分析2010年3月至2013年6月收治的符合入选标准的小肝癌患者113例。按照治疗方式不同,分为开腹组(行开腹手术切除治疗,计60例)与射频组(行开腹射频消融治疗,计53例),比较两组患者术后不同时段肝功能变化情况,两组患者术后不良反应发生情况以及术后1年,2年以及3年时的总生存率以及肿瘤复发率。结果 两组患者丙氨酸氨基转移酶(ALT)在术后先升高后降低,胆碱酯酶(ChE)在术后逐渐降低,射频组ALT水平以及ChE水平在术后第1天、第3天以及第7天均显著低于开腹组,差异有统计学意义(t=4.979、2.158、3.522,P<0.05)。两组患者术后均有不同程度的并发症出现,射频组术后发生高热2例,显著少于开腹组8例(χ 2=4.160,P=0.041)。开腹组术后3年总生存率及肿瘤复发率为60.00%和38.33%,射频组则为64.15%和39.62%,两组差异无统计学意义(χ2=0.020,P＝0.888)。结论 和开腹手术相比,开腹射频消融治疗小肝癌具有创伤小,对肝功能影响小的优势,能达到与手术治疗相同的生存率。 |
| 英文摘要: |
| Objective To explore the clinical effect and security of open abdominal radiofrequency ablation and laparotomy in the treatment of small hepatocellular cancer. Methods Retrospective analyzed of 113 patients with small hepatocellular cancer admitted to our hospital from March 2010 to June 2013. According to the different treatment, divided into the control group (open abdominal radiofrequency ablation group) and the observation group (open radiofrequency ablation group), compared the liver function different period of time of treatment of two groups,the incidence of adverse events after operation and the overall survival rate and recurrence rate at 1 year, 2 years and 3 years after operation. Results ALT in the two groups after surgery increased then decreased.ChE (cholinesterase) gradually reduced in the postoperative. The levels of ALT and ChE in the observation group were significantly lower than those in the control group at 1 day, 3 day and 7day after operation, the difference was statistically significant (t=4.979,2.158,3.52, P<0.05). There were different degrees of complications in the two groups, and the number of hyperthermia in the observation group was 2,which was significantly lower than the mumber which was 8 in the control group (χ2=4.160,P=0.041). In the open group, the overall survival rate and tumor recurrence rate were 60.00% and 38.33% at three years after operation, while 64.15% and 39.62% respectively in the radio frequency group.There was no statistically significant difference between the two groups (χ2=0.020,P＝0.888).Conclusion Open abdominal radiofrequency ablation for small hepatocellular carcinoma (HCC) with a small surgical trauma, small impact on the liver function, can achieve the same overall survival rate compare surgical treatment. |
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