| 刘超,李长钢.儿童急性淋巴细胞白血病继发噬血细胞综合征1例[J].安徽医药,2018,22(7):1363-1365. |
| 儿童急性淋巴细胞白血病继发噬血细胞综合征1例 |
| A case report of the secondary hemophagocytic syndrome in children with acute lymphoblastic leukemia |
| 投稿时间：2017-08-23 |
| DOI： |
| 中文关键词: 前体细胞淋巴母细胞白血病淋巴瘤 淋巴组织细胞增多症, 嗜血细胞性 病理状态, 体征和症状 预后 儿童 |
| 英文关键词: Precursor cell lymphoblastic leukemia-lymphoma Lymphohistiocytosis, hemophagocytic Pathological conditions, signs and symptoms Prognosis Child |
| 基金项目: |
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| 摘要点击次数: 1952 |
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| 中文摘要: |
| 目的 探讨儿童急性淋巴细胞白血病继发噬血细胞综合征的临床特征、预后及发生的可能原因。方法 收集1例确诊的“急性淋巴细胞白血病”患儿继发“噬血细胞综合征”病例,回顾性分析其原发病、临床表现、实验室检查指标、治疗与转归特点,并复习相关文献。结果 骨髓细胞学涂片诊断为急性淋巴细胞白血病ALL-L1,白细胞细胞免疫分型检测符合Common-B-ALL表型,原始及幼稚淋巴细胞比例占37.8%。噬血细胞综合征确诊后,按照HLH-2004化疗方案进行治疗,3个月后患儿死亡。结论 儿童急性淋巴细胞白血病继发噬血细胞综合征来势凶险,临床表现各异,常伴有多脏器功能损害；常规治疗效果差,死亡率高。 |
| 英文摘要: |
| Objective To investigate the clinical characteristics, prognosis and possible causes of the secondary hemophagocytic syndrome in children with acute lymphoblastic leukemia. Methods The primary disease, clinical manifestations, laboratory examination indicators, treatment and prognosis characteristics of a case confirmed was collected and the literatures reviewed. Results After the acute lymphoblastic leukemia of children was diagnosed to secondary hemophagocytic syndrome, HLH-2004 chemotherapy program implemented. The children died soon. Conclusion This disease is dangerous, with varied clinical manifestations and often accompanied by multiple organ dysfunction. The outcome are bad and mortality is high. |
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