| 薛秀丽,李玉华,王荣良,等.早期应用静脉注射用丙种球蛋白治疗百日咳综合征疗效分析[J].安徽医药,2018,22(9):1817-1821. |
| 早期应用静脉注射用丙种球蛋白治疗百日咳综合征疗效分析 |
| Clinical curative effect of the application of gamma globulin on the treatment of babies with pertussis syndrome |
| 投稿时间：2017-01-13 |
| DOI： |
| 中文关键词: 静脉注射用丙种球蛋白 百日咳综合征 临床疗效 生活质量 |
| 英文关键词: Gamma globulin Pertussis syndrome Clinical curative effect Quality of life |
| 基金项目:承德市科学技术研究与发展计划项目(201606A011)早期应用静脉注射用丙种球蛋白治疗百日咳综合征疗效分析 薛秀丽1,李玉华1,王荣良1,马兵2,左继华3,冀楠4 (1.承德市妇幼保健院儿科,河北 承德 067000;2.承德市妇幼保健院新生儿科,河北 承德 067000；3.平泉县医院急诊科,河北 承德 067500；4.隆化县隆化镇医院妇产科,河北 承德 068150) |
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| 中文摘要: |
| 目的 分析百日咳综合征患儿早期应用静脉注射用丙种球蛋白进行治疗的临床疗效以及对患儿生活质量的影响。方法 收集2011年3月至2016年6月承德市妇幼保健院治疗的百日咳综合征的患儿200例,按照随机数字表法将患儿分为两组,每组100例。对照组应用大环内酯类抗生素进行治疗,治疗组应用大环内酯类抗生素+静脉注射用丙种球蛋白治疗,观察患儿临床疗效、痉咳消失时间、治疗时间、治疗前后主要症状评分及LCQ量表评分。结果 患儿入院治疗1个月内,治疗组痊愈例数96例(占比96%)显著好于对照组(87例,87%)(Z=-2.291,P=0.022)。治疗组66例(占比68.75%)患儿痉咳消失时间≤2周明显高于对照组(43例,49.43%)(χ2=8.437,P=0.024)。治疗组患儿住院时间在2周左右,而对照组在3周左右。治疗组患儿应用静脉注射用丙种球蛋白治疗后主要症状评分降低了4.07分,而对照组降低了2.96分,治疗组与对照组相比,患儿主要症状得到显著改善(P<0.05)。治疗组LCQ各项目评分平均值为5.87分,对照组为4.96分,治疗组显著高于对照组(P<0.05)。结论 百日咳综合征患儿患病初期应用丙种球蛋白结合大环内酯类抗生素进行治疗,可提高治愈率、缩短住院时间、减轻患儿患病症状、提高患儿生活质量。 |
| 英文摘要: |
| Objective To analyze the clinical curative effect of the application of gamma globulin in early phase on the treatment of babies with pertussis syndrome,and to study its impact on the life quality of sick babies. Methods From March 2011 to June 2016,0 cases of children with pertussis syndrome treated at Chengde Maternal and Child Health Hospital were collected. According to the random number table method,200 cases were divided into two groups with 100 cases in each group.The control group was treated with macrolide antibiotics and the treatment group was treated with macrolide antibiotics + gamma globulin.The curative effect,spasmodic cough disappeared time,time of therapy,the main symptoms score before and after treatment and LCQ score were observed. Results Within 1 month of hospitalization,and in the treatment group,the cure rate (96%) and the number of cured cases (96 cases) were both significantly better than the control group(87%,87 cases)(Z=-2.291,P=0.022).The number of cases (66 cases) and the proportion (68.75%) of spasmodic cough disappeared time in the treatment group was significantly higher than that in the control group within 2 weeks (43 cases,49.43%)(χ2=8.437,P=0.024),The hospital stay was about 2 weeks in the treatment group and about 3 weeks in the control group.In the treatment group,the main symptom score of the treatment group decreased by 4.07,while that of the control group was 2.96.Compared with the control group,the main symptom of the treatment group was significantly improved (P<0.05).The average score of LCQ in the treatment group was 5.87 and that in the control group was 4.96.The treatment group was significantly higher than the control group (P<0.05). Conclusions In early phase,applying gamma globulin combined with macrolides antibiotics to treat the babies with pertussis syndrome that could improve the cure rate,shorten the hospitalization time,relieve the symptoms and improve the quality of life during therapy. |
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