| 孟景晔,骆子义,朱惠敏.杀鼠药中毒所致凝血功能障碍20例临床分析[J].安徽医药,2018,22(10):1892-1893. |
| 杀鼠药中毒所致凝血功能障碍20例临床分析 |
| Clinical analysis of 20 patients with coagulation disorder induced by rodenticide poisoning |
| 投稿时间：2017-02-10 |
| DOI： |
| 中文关键词: 中毒 香豆素类 苯茚二酮 血液凝固因子 维生素K1 |
| 英文关键词: Poisoning Coumarins Phenindione Blood coagulation factors Vitamin K1 |
| 基金项目:深圳市科技创新委资助项目(20150327204626) 杀鼠药中毒所致凝血功能障碍20例临床分析孟景晔,骆子义,朱惠敏 (深圳市第三人民医院血液科,广东 深圳 518112) 杀鼠药中毒所致凝血功能障碍20例临床分析孟景晔,骆子义,朱惠敏 Clinical analysis of 20 patients with coagulation disorder induced by rodenticide poisoning MENG Jingye,LUO Ziyi,ZHU Huimin |
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| 中文摘要: |
| 目的 总结杀鼠药中毒导致的凝血功能障碍的临床诊断及治疗。 方法 对20例抗凝血杀鼠药中毒致凝血功能障碍患者予以维生素K1治疗,比较患者治疗前后的凝血功能改变:凝血酶原时间(PT)、国际正常化比率( INR ),活化部分凝血活酶时间(APTT)、凝血因子Ⅱ、Ⅶ、Ⅸ、Ⅹ活性。 结果 20例患者全部治愈,治疗前后凝血功能明显改变,PT治疗前后分别为:(103.2±20.3)s,(12.0±0.5)s。 INR治疗前后分别为:4.2±2.4,1.4±0.2。APTT 治疗前后分别为:(93.2±25.4)s,(30.2±3.4)s。凝血因子Ⅱ:活性成分治疗前后分别为:(6.2±2.5)%,(92.3±4.5)%。凝血因子Ⅶ:活性成分治疗前后分别为:(10.8±4.9)%,(86.2±3.4)%。凝血因子Ⅸ:活性成分治疗前后分别为:(22.5±6.8)%,(96.4±7.8)%。凝血因子X:活性成分治疗前后分别为:(14.2±3.2)%,(83.2±3.4)%,差异有统计学意义(P<0.001)。 结论 杀鼠药中毒致凝血功能障碍,容易误诊,维生素K1是特效解毒药。 |
| 英文摘要: |
| Objective To summarize the clinical diagnosis and therapeutic methods about disturbance of blood coaguation induced by rodenticide poisoning. Methods Twenty patients were treated with vitamin K1,the changes of coagulation function before and after treatment including prothrombin time (PT),international normalization ratio (INR),activated partial thromboplastin time (APTT),and coagulation factor Ⅱ,Ⅶ,Ⅸ,Ⅹ activity were compared. Results All the patients were cured.There was obvious difference between before and after treatment in the blood clotting index (P<0.001).Before and after treatment,PT was (103.2±20.3)s,(12±0.5)s respectively;INR was (4.2±2.4),(1.4±0.2),respectively;APTT was (93.2±25.4)s,(30.2±3.4)s, respectively;Ⅱ:C was (6.2±2.5)%,(92.3±4.5)%,respectively;Ⅶ:C was (10.8±4.9)%,(86.2±3.4)%,respectively;Ⅸ:C was (22.5±6.8)%,(96.4±7.8)%,respectively;Ⅹ:C was (14.2±3.2)%,(83.2±3.4)%,respectively,and the differences were statistically significant (P<0.001). Conclusions Coagulation disorder induced by rodenticide poisoning is easy to misdiagnose,the therapy with vitamin K1 is a specific antidote. |
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