| 薛晓拉,夏玉朝,王延涛,等.质子泵抑制剂致肝损害3例并文献复习[J].安徽医药,2018,22(12):2468-2469. |
| 质子泵抑制剂致肝损害3例并文献复习 |
| Proton pump inhibitors-induced liver injury:analysis of 3 cases and literature review |
| 投稿时间：2017-04-06 |
| DOI： |
| 中文关键词: 质子泵抑制剂 肝损害 合理用药 |
| 英文关键词: Proton pump inhibitors Liver injury Rational drug use |
| 基金项目: |
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| 中文摘要: |
| 目的 提高对质子泵抑制剂(PPIs)致肝损害不良反应的认识。 方法 报道3例使用PPIs出现肝损害病例,并检索相关文献进行文献复习。 结果 PPIs具有肝毒性,且女性为高危人群,及时停药并进行保肝治疗一般预后良好。 结论 PPIs可引起肝损害,使用PPIs的患者应定期监测肝功能,出现乏力、皮肤黄染等症状应及时评估其与PPIs之间的关系,及早发现、及时治疗可避免严重肝损害的发生。 |
| 英文摘要: |
| Objective The present study was to deepen our understanding on proton pump inhibitors-induced liver injury. Methods Three cases of liver injury caused by the use of proton pump inhibitors (PPIs) were reported and the pertinent literature were reviewed. Results PPIs-induced hepatotoxicity was more likely to happen in female.The patients always had a good recovery if withdrawal in time. Conclusion PPIs may induce liver injury.The patients who used PPIs should monitor liver function timely.Once exhausted or jaundice of the skin appeared,the physician should evaluate the relationship between the discomfort and PPIs usage.Severe adverse reactions could be avoided when discovered and treated as early as possible. |
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