| 徐曼秋,费素娟.机械敏感性离子通道Piezo2的研究进展[J].安徽医药,2019,23(2):217-220. |
| 机械敏感性离子通道Piezo2的研究进展 |
| Research progress of mechanosensitive ion channel Piezo2 |
| 投稿时间：2017-05-18 |
| DOI： |
| 中文关键词: Piezo2 本体感觉 轻触觉 疼痛 肿瘤 |
| 英文关键词: Piezo2 Proprioception Light touch Pain Tumor |
| 基金项目: |
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| 中文摘要: |
| Piezo2是将小核糖核酸干扰技术应用于小鼠Neuro2A细胞系而发现的一种新型机械力敏感非选择性阳离子通道。其对阳离子的渗透率为Ca2+>K+>Na+>Mg2+。它能够感受机械刺激并将其转化为电信号,参与轻触觉、本体感觉、机械性痛觉超敏、肿瘤血管生成等多种病理生理过程。该文现就Piezo2的结构、调节、功能等进行综述。 |
| 英文摘要: |
| Piezo2 is a novel mechanosensitive non-selective cation channel discovered by applying small RNA interference technology to mouse Neuro2A cell line.The rank order of its permeability to cations is Ca2+>K+>Na+>Mg2+.Piezo2 is responsible for the perception of mechanical stimulus and then transfers them into electrical signals.This channel plays an important role in many pathophysiological processes,such as light touch,proprioception,mechanical allodynia,tumor angiogenesis and so on.This review summarizes the current knowledge on Piezo2 structure,regulation,function,etc. |
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