| 曹琳,宋晓文,任金来,等.血清淀粉样蛋白A的研究进展[J].安徽医药,2019,23(2):221-224. |
| 血清淀粉样蛋白A的研究进展 |
| Advances in research on serum amyloid A |
| 投稿时间：2017-04-16 |
| DOI： |
| 中文关键词: 血清淀粉样蛋白A 急性时相反应蛋白 类风湿性关节 2型糖尿病 动脉粥样硬化 |
| 英文关键词: Serum amyloid A Acute phase protein Rheumatoid arthritis Diabetes type 2 Atherosclerosis |
| 基金项目: |
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| 中文摘要: |
| 血清淀粉样蛋白A(SAA)是组织淀粉样蛋白A的前体物质,是急性时相反应蛋白之一,在机体受到感染、创伤、炎症等损伤后,SAA水平迅速升高。近年来,随着对SAA的基因调控、蛋白结构及生物学功能研究的深入,发现SAA也参与慢性炎性疾病发病过程。该文现就SAA家族的基因结构、生物学功能及在慢性炎性疾病中的应用进行综述。 |
| 英文摘要: |
| Serum amyloid A (SAA) is precursor of the tissue amyloid A,and it is one of the acute phase proteins.Serum amyloid Awould be increased under the conditions of infection,tissue damage and inflammation.In recent years,with further studies on the gene regulation,protein structure and biological function of SAA,it has been found that SAA is also involved in the pathogenesis of chronic inflammatory diseases.This article reviewed the genetic structure and biological function of SAA family and its application in the diagnosis and treatment of chronic inflammatory diseases. |
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