PIK3CA rs4975596基因多态性与口腔癌的相关性研究

张永春; 王志强; 孙晶晶; 宋荣学; 王冶

文章摘要

张永春,王志强,孙晶晶,等.PIK3CA rs4975596基因多态性与口腔癌的相关性研究[J].安徽医药,2019,23(2):254-256.

PIK3CA rs4975596基因多态性与口腔癌的相关性研究

Research on the correlation between gene polymorphism of PIK3CA rs4975596 and oral squamous cellcarcinoma

投稿时间：2017-07-17

DOI：

中文关键词: PIK3CA 口腔癌基因多态性

英文关键词: PIK3CA Oral squamous cell carcinoma Polymorphism

基金项目:

作者	单位
张永春	赤峰学院附属医院口腔颌面外科,内蒙古赤峰 024005
王志强	赤峰学院附属医院口腔颌面外科,内蒙古赤峰 024005
孙晶晶	赤峰学院附属医院口腔颌面外科,内蒙古赤峰 024005
宋荣学	赤峰学院附属医院口腔颌面外科,内蒙古赤峰 024005
王冶	赤峰学院附属医院口腔颌面外科,内蒙古赤峰 024005

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中文摘要:

目的探讨PIK3CA rs4975596单核苷酸多态性与口腔癌发生的相关性。方法应用聚合酶链反应检测PIK3CA rs4975596基因多态性,比较口腔癌组与健康人群PIK3CA rs4975596基因型的分布频率差异以及等位基因频率差异。结果 50例口腔癌组和50例健康人群对照组PIK3CA rs4975596基因型分布频率野生型AA分别为52%和68%,杂合型AG分别为28%和24%,突变型GG分别为20%和8%,两组比较差异有统计学意义(χ²=7.073,P=0.029);等位基因频率野生型A分别为65%和76%,突变型G分别为35%和24%,两组比较差异有统计学意义(χ²=5.360,P=0.024)。口腔癌组与健康人群对照组PIK3CA rs4975596基因型分布频率和等位基因频率差异有统计学意义。结论口腔癌的发生可能与PIK3CA rs4975596基因型多态性具有某种关联。

英文摘要:

Objective To study the correlation between gene polymorphism of PIK3CA rs4975596 and oral squamous cell carcinoma.Methods PIK3CA rs4975596 polymorphism was detected by means of polymerase chain reaction.The distribution and allele frequency of PIK3CA rs4975596 genotype in oral squamous cell carcinoma group and healthy control group were compared.Results Among 50 cases of oral squamous cell carcinoma patients and 50 healthy volunteers,PIK3CA rs4975596 wild AA genotype frequencies were 52% and 68%,heterozygous AG genotype frequencies were 28% and 24%,and mutant GG genotype frequencies were 20% and 8% (χ²=7.073,P=0.029).Wild-type Aallele frequencies were 65% and 76%,mutant Gallele frequencies were 35% and 24% (χ²=5.360,P=0.024).The differences in PIK3CA rs4975596 genotype distribution and allele frequencies between oral squamous cell carcinoma group and healthy control group were significant.Conclusions The occurrence of oral squamous cell carcinoma may be related to PIK3CA rs4975596 polymorphism.

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