| 方芳,张开光,吴正祥.成人无确定性过敏原的嗜酸性粒细胞胃肠炎的临床分析[J].安徽医药,2019,23(2):277-279. |
| 成人无确定性过敏原的嗜酸性粒细胞胃肠炎的临床分析 |
| A clinical study of eosinophilic gastroenteritis in adults without certain allergens |
| 投稿时间：2017-06-06 |
| DOI： |
| 中文关键词: 嗜酸性粒细胞胃肠炎 嗜酸性粒细胞 临床特点 诊断 治疗 |
| 英文关键词: Eosinophilic gastroenteritis Eosinophil Clinical manifestation Diagnosis Therapy |
| 基金项目: |
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| 摘要点击次数: 1709 |
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| 中文摘要: |
| 目的 探讨无确定过敏原的嗜酸性粒细胞胃肠炎的临床特点、诊断、治疗及预后。方法 对11例在安徽省立医院2009年1月至2016年12月住院,并确诊嗜酸性粒细胞胃肠炎成人病人的病史、临床表现、实验室及影像检查、内镜及病理学检查、治疗及随访情况进行回顾性分析。结果 该研究中8例病人血中白细胞升高,10例外周血嗜酸性粒细胞计数升高。黏膜型(8例)最为常见,且以腹痛、腹泻为首发或主要临床表现。内镜下多部位(6例)累及,主要表现为黏膜充血水肿、糜烂、溃疡,以十二指肠最为明显,活检或腹水见大量嗜酸性粒细胞浸润可确诊。单部位4块或以上组织或多部位活检可提高病理检测阳性率。激素或激素联合抗感染(7例)治疗、单纯抗感染(4例)治疗均可缓解症状,降低嗜酸性粒细胞,预后良好。结论 外周血嗜酸性粒细胞增加对嗜酸性粒细胞胃肠炎有提示作用,确诊仍有赖于组织或腹水病理学。感染可能是无过敏史嗜酸性粒细胞胃肠炎诱因或病因之一,单纯抗感染和抗感染联合糖皮质激素治疗同样有效,总体预后良好。 |
| 英文摘要: |
| Objective To investigate the clinical features,diagnosis,treatment and prognosis of eosinophilic gastroenteritis (EG) without certain allergens.Methods Eleven cases of EG who were hospitalized in Anhui Provincial Hospital from January 2009 to December 2016 were enrolled.The data of medical history,clinical manifestations,laboratory and imaging examination,endoscopic and pathological test,treatment,and follow-up were analyzed retrospectively.Results In this study,8 patients had elevated white blood cells,and 10 patients had elevated eosinophil counts.Mucosal type (8 cases) is the most common,with abdominal pain or diarrhea as the initial or main clinical manifestation.Endoscopic exam showed that multiple sites (6 cases) were involved.The main manifestations were mucosal congestion and edema,erosion,ulcers,with duodenum as the most obvious site.Diagnosis could be confirmed by abundant eosinophil infiltration indicated by biopsy or ascites.Biopsy of 4 or more tissues in a single site or multiple sites increased the positive rate of pathology.Hormone or hormone combined with anti-infection therapy (7 cases) and simple anti-infection therapy (4 cases) could alleviate symptoms,reduce eosinophil count,and achieved a good prognosis.Conclusions The increase of eosinophil in peripheral blood has a suggestive effect on EG.The diagnosis still depends on the pathological tests of tissues or ascites.Infection may be one of the causes of non-allergic eosinophilic gastroenteritis.Simple anti-infection and anti-infection combined with glucocorticoid therapy is equally effective,and the overall prognosis of the disease is good. |
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