| 严丽,龚建忠,孔令怡.2型糖尿病病人踝臂指数与尿微量白蛋白/肌酐比值的相关性分析[J].安徽医药,2019,23(2):313-316. |
| 2型糖尿病病人踝臂指数与尿微量白蛋白/肌酐比值的相关性分析 |
| Correlation analysis of ankle brachial index and urine trace albumin/creatinine ratio in patients with type 2 diabetes |
| 投稿时间：2017-03-18 |
| DOI： |
| 中文关键词: 尿微量白蛋白/肌酐比值 2型糖尿病 糖尿病肾病 相关性 踝臂指数 |
| 英文关键词: Urine trace albumin/creatinine ratio Type 2 diabetes Diabetic nephropathy Correlation Ankle brachial index |
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| 中文摘要: |
| 目的研究并分析2型糖尿病病人踝臂指数(ABI)与尿微量白蛋白/肌酐比值(ACR)的相关性。方法 回顾性分析2014年4月至2016年8月海南省洋浦开发区医院收治的2型糖尿病病人200例的资料,分别对所有病人的ABI水平进行测定,并根据结果分为ABI下降组(52例)与ABI正常组(148例)。对比两组病人年龄、病程、收缩压、舒张压、白细胞计数、C-反应蛋白、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、糖化血红蛋白水平以及ACR情况,同时,将ABI下降组病人分为轻度下降组(34例)与中度下降组(18例),对比两组病人的ACR情况。并作相关分析。结果 两组年龄、性别、病程比较均差异无统计学意义(均P＞0.05)。两组病人收缩压、舒张压、白细胞计数、C-反应蛋白、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、糖化血红蛋白水平对比,均差异无统计学意义(均P＞0.05)。而ABI下降组病人的ACR为(2.5±0.5) g/mol,高于ABI正常组病人的(1.4±0.3) g/mol,差异有统计学意义(t=49.362,P＜0.001)。ABI轻度下降组病人ACR异常率为58.82%(20/34),与ABI中度下降组的88.89%(16/18)比较,差异有统计学意义(χ2=4.994,P=0.025)。经Spearman相关性分析可得,2型糖尿病病人ABI与ACR呈负相关关系(r=-0.523,P <0.001)。经多因素logistic回归分析发现,ACR是影响2型糖尿病病人ABI的危险因素。结论 2型糖尿病病人ABI与ACR呈显著负相关关系,提示了ABI水平的变化可作为临床上早期糖尿病肾病的预测指标。 |
| 英文摘要: |
| Objective To study and analyze the relationship between ankle brachial index (ABI) and urine trace albumin/creatinine ratio (ACR) in patients with type 2 diabetes.Methods Two hundred patients with type 2 diabetes mellitus in Hospital of Yangpu Development Zone from April 2014 to August 2016 were retrospectively analyzed.The level of ABI in patients was measured,and according to the results,patients were assigned into ABI decline group (52 cases) and ABI normal group (148 cases).Patients' age,course of the disease,systolic blood pressure,diastolic pressure,white blood cell count,C-reactive protein,triglyceride,total cholesterol,high-density lipoprotein cholesterol,glycated hemoglobin levels and ACR were compared between two groups.At the same time,ABI decline group was assigned into mild decline group (34 cases) and moderate decline group (18 cases).ACR of the two groups was compared and correlation analyzed.Results The differences in age,gender,contrast in course of disease,systolic blood pressure,diastolic pressure,white blood cell count,C-reactive protein,triglyceride,total cholesterol,high-density lipoprotein cholesterol,glycated hemoglobin level were no statistically significant between the two groups (all P>0.05).ACR in ABI decline group was (2.5±0.5) g/mol,which was higher than that in ABI normal group (1.4±0.3) g/mol,and the difference was statistically significant (t=49.362,P＜0.001).The abnormal rates of ACR in ABI mild decline group and ABI moderate decline group were 58.82% (20/34),88.89% (16/18),respectively,and the difference was statistically significant (χ2=4.994,P=0.025).Spearman correlation analysis results showed that ABI was negatively correlated with ACR in patients with type 2 diabetes (r=-0.523,P<0.001).The multi-factor logistic regression analysis found that ACR was a risk factor for ABI in patients with type 2 diabetes.Conclusions There was significantly negative relationship between ABI and ACR in patients with type 2 diabetes,suggesting that changes in ABI level can be used as clinical predictors of early diabetic nephropathy. |
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