| 王亮,刘洪军,李春,等.伊马替尼治疗儿童慢性粒细胞白血病发生急淋变2例报告及文献复习[J].安徽医药,2019,23(2):340-343. |
| 伊马替尼治疗儿童慢性粒细胞白血病发生急淋变2例报告及文献复习 |
| Imatinib for the treatment of 2 children with acute lymphocytic blast crisis of chronic myelogenous leukemia:case report and literature review |
| 投稿时间：2017-03-01 |
| DOI： |
| 中文关键词: 慢性粒细胞白血病 儿童 急性变 伊马替尼 |
| 英文关键词: Chronic myelogenous leukemia (CML) Child Lymphocytic blast crisis Imatinib |
| 基金项目: |
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| 中文摘要: |
| 目的探讨伊马替尼治疗儿童慢性粒细胞白血病(CML)过程中发生急淋变的治疗经验。方法 纳入安徽省肿瘤医院2015年8月及2016年6月收住的2例儿童CML口服伊马替尼治疗过程中发生急淋变病人,统计达到血液学反应(CHR)时间、定期复查骨髓细胞学及融合基因、染色体。确定儿童CML急淋变后予以“达沙替尼+改良VDLP” 方案化疗,骨髓缓解后积极行异基因造血干细胞移植(HSCT)。结果 2例病人分别于口服伊马替尼后第18天及第33天达到CHR,1年后Ph染色体均未转阴,且发生急淋变。确定儿童CML急淋变后予以“达沙替尼+改良VDLP” 方案化疗,骨髓均得到缓解,2例HSCT均顺利完成。结论 伊马替尼治疗儿童CML过程中发生急淋变后,予以改用达沙替尼及改良VDLP方案化疗,并予以HSCT,患儿预后良好。 |
| 英文摘要: |
| Objective To investigate the experience in treating children with chronic myelogenous leukemia (CML) with Imatinib.Methods Two children with acute lymphocytic blast crisis of CML treated with oral Imatinib were included in the study,who were admitted to Department of Pediatric Hematology,Anhui Provincial Cancer Hospital from August 2015 to June 2016.The hematological response (CHR) time was counted,and the bone marrow cytology,fusion genes and chromosomes were reviewed regularly.Children with CML were determined to receive chemotherapy with “Dasatinib+modified VDLP" regimen after acute lymphocytic blast crisis,and to actively undergo allogeneic hematopoietic stem cell transplantation (HSCT) after bone marrow remission.Results The two patients reached CHR on the 18th day and the 33rd day after the oral administration of Imatinib,respectively.After 1 year,the Ph chromosome did not turn negative,and the patients developed acute lymphocytic blast crisis.After the determination of acute lymphocytic blast crisis in children with CML,chemotherapy with “Dasatinib + modified VDLP” regimen was given,and the bone marrow was relieved,and both cases of HSCT were successfully completed.Conclusions After acute lymphocytic blast crisis occurred during Imatinib treatment of children with CML,Dasatinib and modified VDLP chemotherapy were used,and HSCT was given.The prognosis of the children was good. |
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