| 赵冰封,黄学桂,赵晗,等.国产与进口卡前列素氨丁三醇治疗产后出血的疗效与成本效果分析[J].安徽医药,2019,23(2):354-356. |
| 国产与进口卡前列素氨丁三醇治疗产后出血的疗效与成本效果分析 |
| Curative and cost-effectiveness analysis of domestic and imported Carboprost Tromethamine in the treatment of postpartum hemorrhage |
| 投稿时间：2017-05-19 |
| DOI： |
| 中文关键词: 卡前列素氨丁三醇 国产 临床疗效 成本效果分析 |
| 英文关键词: Carboprost Tromethamine Domestic Clinical efficacy Cost-effectiveness analysis |
| 基金项目:合肥市科技计划自筹项目(2013-17) ◇药物与临床◇国产与进口卡前列素氨丁三醇治疗产后出血的疗效与成本效果分析赵冰封,黄学桂,赵晗,包旻(安徽医科大学附属妇幼保健院,安徽 合肥 230001) |
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| 中文摘要: |
| 目的 评价国产与进口卡前列素氨丁三醇治疗产后出血的有效性、安全性与经济性。方法 收集2016 年1—12月安徽医科大学附属妇幼保健院收治的400例产妇资料,将产妇依据治疗方式不同分为对照组和观察组,每组200例。对照组给予进口卡前列素氨丁三醇注射液治疗,观察组给予国产卡前列素氨丁三醇注射液治疗。比较两组病人治疗效果并依据药物经济学原理对其药物的成本效果进行评价。结果 两组病人一般情况、术后2 h出血量及总出血量、产后24 h血红蛋白(Hb)与红细胞(RBC)下降值、产后止血相关临床干预措施与临床总有效率比较,均差异无统计学意义(P>0.05)；观察组平均药物治疗费用低于对照组(293.23元vs.473.96元),术中出血量与消化系统不良反应发生率均高于对照组,差异有统计学意义(均P<0.05)；观察组与对照组的药物成本效果比分别为3.01、4.81。结论 国产卡前列素氨丁三醇治疗产后出血安全有效,但应注意药物不良反应；经成本效果分析后,国产卡前列素氨丁三醇用于治疗产后出血经济性更佳。 |
| 英文摘要: |
| Objective To evaluate the efficacy,safety and economy of domestic and imported Carboprost Tromethamine in the treatment of postpartum hemorrhage.Methods Data of 400 maternal cases were collected who were treated in Anhui Women and Child Health Care Hospital from January 2016 to December 2016.They were assigned into two groups according to different treatment methods,with 200 cases in each group.The control group received the imported carboprost tromethamine injection treatment,while the observation group received domestic carboprost tromethamine injection treatment.The efficacies of the two groups were compared and the cost-effectiveness of the medical treatment was evaluated according to the pharmacoeconomics principles.Results There were no significant differences in general condition,2 h postoperative blood loss,total blood loss,24 h postpartum decreased values of hemoglobin (Hb) and erythrocyte (RBC),postpartum hemostasis-related clinical intervention and clinical total effective rate between two groups (P>0.05).The average drug treatment costs of control group was significantly higher than observation group (293.23 yuan vs.473.96 yuan),but the incidence of intraoperative blood loss and the incidence of adverse reactions in the digestive system were significantly higher,and the differences were statistically significant (all P<0.05).The drug cost-effectiveness ratios of the control group and observation group were 3.01,4.81 respectively.Conclusions Domestic Prostaglandin Tromethamine is safe and effective in the treatment of postpartum hemorrhage,but the adverse drug reactions should be attached importance to.After cost-effectiveness analysis,domestic Carboprost Tromethamine is more economical for the treatment of postpartum hemorrhage. |
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