| 张星,金山,张喜平,等.内补黄芪汤联合胸腺五肽对改良根治术后乳腺癌病人免疫功能的影响[J].安徽医药,2019,23(2):372-375. |
| 内补黄芪汤联合胸腺五肽对改良根治术后乳腺癌病人免疫功能的影响 |
| Effect of Neibu Huangqi decoction combined with thymopentin on immune function in patients with breast cancer after modified radical mastectomy |
| 投稿时间：2017-09-14 |
| DOI： |
| 中文关键词: 内补黄芪汤 胸腺五肽 乳腺癌改良根治术 免疫功能 |
| 英文关键词: Neibu Huangqi decoction Thymopentin Modified radical mastectomy of breast cancer Immune function |
| 基金项目: |
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| 摘要点击次数: 1827 |
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| 中文摘要: |
| 目的 探讨内补黄芪汤联合胸腺五肽对改良根治术后乳腺癌病人免疫功能的影响。方法 前瞻性收集2015年1月至2016年1月内蒙古医科大学附属医院收治的改良根治术后乳腺癌病人100例,将病人按照完全随机数字表原则分为研究组和对照组,每组50例。研究组术后辅以内补黄芪汤联合胸腺五肽治疗,对照组给予胸腺五肽治疗和安慰剂。主要观察指标包括外周血T细胞亚群(CD4+、CD8+T细胞、CD4+/CD8+T细胞比例)、外周血T细胞因子[白细胞介素-2(IL-2)、白介素-6(IL-6)、白介素-10(IL-10)和肿瘤坏死因子-α(TNF-α)]、住院时间、术后并发症和健康相关的生存质量评分(SF-36)。结果 两组病人术后1 d时CD4+T细胞、CD4+/CD8+T细胞比例、IL-2、IL-6、TNF-α和IL-10水平均差异无统计学意义(均P＞0.05)。病人术后14 d研究组和对照组CD4+T细胞水平分别为(27.53±5.32)%、(24.32±4.52)%,差异有统计学意义(t=3.251,P=0.002)。病人术后14 d研究组和对照组CD4+/CD8+T细胞比例分别为(0.82±0.15)、(0.76±0.15),差异有统计学意义(t=2.000,P=0.048)。病人术后14 d研究组和对照组IL-2水平分别为(4.86±0.51)、(4.37±0.57) μg/L,差异有统计学意义(t=4.530,P=0.000)。病人术后14 d研究组和对照组IL-6水平分别为(25.83±4.82)、(21.73±5.39) ng/L,差异有统计学意义(t=4.009,P=0.000)。术后14 d研究组和对照组TNF-α分别为(11.59±3.59)、(9.21±3.81) ng/L,差异有统计学意义(t=3.215,P=0.002)。术后14 d研究组和对照组IL-10分别为(36.49±8.59)、(40.59±9.23) ng/L,差异有统计学意义(t=2.299,P=0.024)。研究组和对照组住院时间分别为(12.12±2.08)、(13.44±2.50) d,差异有统计学意义(t=2.870,P=0.005)。研究组和对照组的术后肿胀率分别为10.00%、34.00%,差异有统计学意义(χ2=9.306,P=0.002)。研究组和对照组SF-36评分分别为(74.32±6.45)、(68.74±6.34)分,差异有统计学意义(t=4.363,P=0.000)。结论 内补黄芪汤联合胸腺五肽有助于改善改良根治术后乳腺癌病人免疫功能和生存质量。 |
| 英文摘要: |
| Objective To investigate the effect of Neibu Huangqi decoction combined with thymopentin on immune function in patients with breast cancer after modified radical mastectomy.Methods One hundred patients with breast cancer after modified radical mastectomy admitted to The Affiliated Hospital of Inner Mongolia Medical University from January 2015 to January 2016 were randomly assigned into the study group and the control group,50 cases in each group,according to the principle of complete random number table.The study group was treated with the combination of Neibu Huangqi decoction and thymopentin,while the control group was treated with thymopentin and placebo.The main observation indexes were observed,including peripheral blood Tcell subsets (CD4+,CD8+T cells,CD4+/CD8+T cell ratio),peripheral blood Tcells cytokines [Interleukin-2 (IL-2),Interleukin-6 (IL-6),Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α)],hospitalization time,postoperative complications and health-related quality of life (SF-36).ResultsThere were no significant differences in the proportion of CD4+T cells,CD4+/CD8+T cells,IL-2,IL-6,TNF-α and IL-10 between the two groups on 1 day after the operation (all P＞0.05).The CD4+T cell level on 14 days after operation in the study group and the control group were (27.53±5.32)% and(24.32±4.52)% respectively,and the study group was significantly higher than that of the control group (t=3.251,P=0.002).The percentage of CD4+/CD8+T cells in the study group and the control group was(0.82±0.15) and(0.76±0.15),respectively,and the study group was significantly higher than that of the control group (t=2.000,P=0.048).At 14 days after the operation,the IL-2 level of the study group and the control group were(4.86±0.51) μg/L and(4.37±0.57) μg/L,and the study group was significantly higher than that of the control group (t=4.530,P=0.000).At 14 days after operation,the IL-6 level of the study group and the control group were(25.83±4.82) ng/L and(21.73±5.39) ng/L,and the study group was higher than the control group (t=4.009,P=0.000).At 14 days after operation,the TNF-α level of the study group and the control group were(11.59±3.59) ng/L and(9.21±3.81) ng/L,and the study group was higher than the control group (t=3.215,P=0.002).At 14 days after operation,the IL-10 level of the study group and the control group were(36.49±8.59) ng/L and(40.59±9.23) ng/L,and the study group was lower than the control group (t=2.299,P=0.024).The hospitalization time of the patients in the study group and the control group were (12.12±2.08) d and (13.44±2.50) d,and the study group was significantly shorter than the control group (t=2.870,P=0.005).The postoperative swelling rate of the study group and the control group were 10.00% and 34.00%,and the study group was significantly lower than that of the control group(χ2=9.306,P=0.002).The health-related quality of life of the study group and the control group were (74.32±6.45) and (68.74±6.34),and the study group was higher than the control group (t=4.363,P=0.000).Conclusions The combination of Neibu Huangqi decoction and thymopentin is helpful to improve the immune function and quality of life in patients with breast cancer after modified radical mastectomy. |
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