| 张颖,李春耕.柳氮磺吡啶结合地塞米松保留灌肠对中轻度溃疡性直乙状结肠炎疗效的影响[J].安徽医药,2019,23(2):382-385. |
| 柳氮磺吡啶结合地塞米松保留灌肠对中轻度溃疡性直乙状结肠炎疗效的影响 |
| Effect of Sulfasalazine combined with Dexamethasone retention enema in the treatment of mild ulcerative anal-sigmoid colitis |
| 投稿时间：2017-05-13 |
| DOI： |
| 中文关键词: 溃疡性直乙状结肠炎 柳氮磺吡啶 地塞米松 保留灌肠 |
| 英文关键词: Ulcerative anal-sigmoid colitis Sulfasalazine Dexamethasone Retention enema |
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| 摘要点击次数: 1791 |
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| 中文摘要: |
| 目的 评价柳氮磺吡啶结合地塞米松保留灌肠对中轻度溃疡性直乙状结肠炎疗效的影响。方法 选择2014年10月至2016年11月唐山市中医医院治疗的溃疡性直乙状结肠炎病人100例,按随机数字表法分为两组,灌肠组50例病人采用柳氮磺吡啶结合地塞米松保留灌肠治疗,对照组50例病人采用口服柳氮磺吡啶治疗,比较两组病人治疗前后及治疗后2个月的疾病活动度(DAI)评分,比较两组治疗疗效及不良反应发生情况。结果 两组治疗后及治疗后2个月的DAI水平较治疗前有较大幅度的下降,灌肠组在治疗后[(5.83±1.24) 分]及治疗后2个月[(2.48±0.98) 分]的DAI水平显著优于对照组[(4.71±1.12)、(3.86±1.04) 分],差异有统计学意义(F组间=3.39,P=0.031；F时间点=10.23,P=0.000；F交互作用=3.43,P=0.034)；经过8周的治疗,灌肠组病人治疗有效率为96%,显著高于对照组84%的有效率(χ2=4.000,P=0.046)；灌肠组不良反应发生率为10%,显著低于对照组的28%(χ2=5.263,P=0.022)。结论 柳氮磺吡啶结合地塞米松保留灌肠治疗中轻度溃疡性直乙状结肠炎起效快,效果好,不良反应少,值得临床推广。 |
| 英文摘要: |
| Objective To evaluate the efficacy of Sulfasalazine combined with Dexamethasone retention enema in the treatment of mild ulcerative anal-sigmoid colitis.Methods One hundred patients with ulcerative anal-sigmoid colitis who were treated in Tangshan Traditional Chinese Medicine Hospital from October 2014 to November 2016 were enrolled.According to the random number table method,patients were randomly assigned into two groups.Fifty cases in the enema group were treated with willow nitrogen sulfonyl pyridine combined with Dexamethasone retention enema,while 50 cases in the control group were treated with oral willow nitrogen sulfonyl pyridine.The disease activity index (DAI) scores of the two groups before and after treatment and 2 months after treatment,the curative effect and adverse reactions of the two groups were compared.Results The DAI levels of the two groups after treatment and 2 months after treatment were significantly lower than those before treatment.The levels of DAI in the enema group after treatment and 2 months after treatment were significantly higher than those in the control group [(5.83±1.24) points vs. (4.71±1.12) points,(5.83±1.24) points vs. (3.86±1.04) points,respectively],and the difference was statistically significant (Fgroups=3.39,P=0.031;Ftime=10.23,P=0.000;FInteraction effect=3.43,P=0.034).After 8 weeks of treatment,the effective rate of the enema group was 96%,which was significantly higher than 84% of the control group (χ2=4.000, P=0.046).The incidence of adverse reactions in enema group was 10%,which was significantly lower than 28% of the control group (χ2=5.263,P=0.022).Conclusions Sulfasalazine combined with Dexamethasone retention enema in the treatment of mild ulcerative anal-sigmoid colitis has rapid effect,good efficacy and few adverse reactions,which is worthy of clinical promotion. |
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