| 张瑶,屠莹,胡占嵩,等.祛风舒筋丸对佐剂关节炎大鼠免疫调节及血管内皮生长因子、细胞黏附分子-1表达的影响[J].安徽医药,2019,23(3):454-457. |
| 祛风舒筋丸对佐剂关节炎大鼠免疫调节及血管内皮生长因子、细胞黏附分子-1表达的影响 |
| The effect of Qufengshujin pills on immunoregulation and expression of VEGF and ICAM-1 in rats with adjuvant arthritis |
| 投稿时间：2017-05-07 |
| DOI： |
| 中文关键词: 祛风舒筋丸具有较强的抗类风湿关节炎作用,其作用机制可能与抑制体外诱导的T、B淋巴细胞增殖,抑制IL-1β、IL-6及TNF-α等细胞因子生成,抑制VEGF和ICAM-1的表达水平有关。 关键词:祛风舒筋丸 类风湿性关节炎 作用机制 |
| 英文关键词: Qufengshujin Pills Rheumatoid arthritis Mechanism of action |
| 基金项目: |
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| 中文摘要: |
| 目的 研究祛风舒筋丸对佐剂关节炎大鼠免疫调节作用以及对血管内皮生长因子(VEGF)与细胞黏附分子-1(ICAM-1)表达的影响。 方法 建立弗氏完全佐剂关节炎大鼠模型,检测体外诱导脾淋巴细胞增殖水平,血清细胞因子含量以及滑膜VEGF、ICAM-1的表达水平。 结果 祛风舒筋丸能显著抑制模型大鼠足趾肿胀,抑制体外诱导的T、B淋巴细胞增殖,抑制类风湿因子(RF)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)的生成,抑制VEGF、ICAM-1的表达,差异有统计学意义(P<0.05)。 |
| 英文摘要: |
| Objective To study the effect of Qufengshujin Pills on immunoregulation and expression of VEGF and ICAM-1 in rats with adjuvant arthritis. Methods The models of Freund's complete adjuvant-induced arthritis in rats were established to determine splenic lymphocyte proliferation inducted in vitro,serum cytokine content and expression of VEGF and ICAM-1 in synovial membrane. ResultsQufengshujin Pills could significantly inhibit paw edema in rats,inhibit Tand Blymphocytes proliferation inducted in vitro,inhibit the generation of RF,IL-1β,IL-6 and TNF-α,inhibit the expression of VEGF and ICAM-1 with statistics significance(P<0.05). Conclusion Qufengshujin Pills has a strong anti-rheumatoid arthritis effect.The mechanism of action may be related to the inhibition of Tand Blymphocytes proliferation,cytokine generation of IL-1β,IL-6 and TNF-α and expression of VEGF and ICAM-1. |
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