| 吴天军,王光,朱理珂.复方消化酶胶囊(Ⅱ)佐治胆管Ⅱ型奥迪括约肌功能障碍的临床疗效观察[J].安徽医药,2019,23(3):598-600. |
| 复方消化酶胶囊(Ⅱ)佐治胆管Ⅱ型奥迪括约肌功能障碍的临床疗效观察 |
| Clinical research of compound digestive enzymes capsule Ⅱon treating type Ⅱ bile duct of sphincter of Oddi dysfunction |
| 投稿时间：2017-04-13 |
| DOI： |
| 中文关键词: 复方消化酶胶囊(Ⅱ)有助于改善胆囊切除术后肝功能正常的胆管Ⅱ型奥迪括约肌功能障碍病人的腹痛、腹胀症状。 关键词:复方消化酶胶囊(Ⅱ) 胆囊切除术后 胆管Ⅱ型 奥迪括约肌功能障碍 |
| 英文关键词: Compound digestive enzymes capsule (Ⅱ) Post-cholecystectomy Bile duct Ⅱ Sphincter of Oddi dysfunction |
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| 中文摘要: |
| 目的 探讨复方消化酶胶囊(Ⅱ)佐治胆囊切除术后病人胆管Ⅱ型奥迪括约肌功能障碍的临床疗效。 方法 选择胆囊切除术后肝功能正常的胆管Ⅱ型奥迪括约肌功能障碍的病人52例,采用随机数字表法分为对照组和观察组,对照组(26例)给予对症治疗；观察组(26例)在对照组的基础上口服复方消化酶胶囊(Ⅱ)1粒,每天3次,疗程均为6周。观测两组病人用药前后症状的改善程度。 结果(1)观察组和对照组用药6周后腹痛改善总有效率分别为88.46%和57.69%,观察组显著高于对照组(P=0.002)；(2)治疗前后观察组腹痛症状总评分下降幅度显著大于对照组[(4.23±2.49)分比 (2.46±1.56)分,P= 0.040],观察组腹胀症状评分下降幅度亦显著大于对照组[(3.31±1.89)分比 (1.84±1.41)分,P= 0.035]；(3)用药后观察组胆总管直径改善有效率较对照组高(53.85% 比 23.08%,P=0.023)。 |
| 英文摘要: |
| Objective To investigate therapeutic effects of compound digestive enzymes capsule(Ⅱ) on treating type Ⅱ bile duct of sphincter of Oddi dysfunction (SOD) after cholecystectomy via laparoscope. Methods Fifty-two patients with type Ⅱ bile ductof sphincter of Oddi dysfunction with normal liver function were randomly divided into treatment group and control group.Twenty-six patients in control group were given drugs for regulating gastrointestinal motility and sensibility for 6 weeks.Besides,a low-fat diet and inhibition of gastric acid secretion were provided.Twenty-six patients in the therapeutic group were given compound digestive enzymes capsule (Ⅱ) (1 pill,3 times daily,before meals) for 6 weeks on the basis of administration in control group.Changes of clinical symptoms and side effects were evaluated. Results The total effective rates for abdominal pain symptoms were 57.69% and 88.46% in control group and theraputic group respectively.There was significant difference between the two groups (P=0.002).Descender span for abdominal pain and abdominal distention symptoms score had obvious difference between treatment group and control group (abdominal pain:4.23±2.49 vs. 2.46±1.56,P=0.040;abdominal distention:3.31±1.89 vs. 1.84±1.41,P=0.035).Common bile duct diameter in theraputic group were obviously improved compared with control group(53.85% vs. 23.08%,P=0.023). Conclusion Treatment with compound digestive enzymes capsule(Ⅱ) may help to relieve symptom of bile duct Ⅱ of sphincter of Oddi dysfunction with normal liver function after cholecystectomy,including abdominal pain and abdominal distention. |
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