| 梁宾.肠内营养联合益生菌治疗重症颅脑损伤后胃肠功能紊乱的临床疗效观察[J].安徽医药,2019,23(3):605-607. |
| 肠内营养联合益生菌治疗重症颅脑损伤后胃肠功能紊乱的临床疗效观察 |
| Timely intervention therapy in severe craniocerebral injury patients with gastrointestinal dysfunction after the clinical efficacy of research |
| 投稿时间：2017-07-21 |
| DOI： |
| 中文关键词: 经鼻胃管开始肠内营养联合益生菌治疗重症颅脑损伤后胃肠功能紊乱的临床疗效显著,可有效改善病人营养状态,促进康复。 关键词:重症颅脑损伤 胃肠功能紊乱 肠内营养 益生菌 营养状况 |
| 英文关键词: Severe craniocerebral injury Gastrointestinal dysfunction Enteral nutrition Probiotics Nutritional status |
| 基金项目: |
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| 中文摘要: |
| 目的 观察肠内营养联合益生菌治疗重症颅脑损伤后胃肠功能紊乱的临床疗效。 方法 选取2015年2月至2017年2月平乡县人民医院收治的重症颅脑损伤后胃肠功能紊乱病人200例,采用随机数字表法分为观察组和对照组,每组100例。对照组病人入院24～72 h内予以经鼻胃管开始肠内营养治疗,观察组病人则在对照组的基础上加用益生菌治疗。所有病人均进行为期1 5d的治疗。分别对比两组病人临床疗效,治疗第1天及第15天营养生化指标、格拉斯哥昏迷分级(GCS)评分、APACHEⅡ评分以及SOFA评分变化情况。 结果 观察组病人临床治疗优良率为93.00%(93/100),显著高于对照组的82.00%(82/100),差异有统计学意义(P＜0.05)。治疗后第15天观察组病人的前白蛋白、转铁蛋白水平分别为(234.5±60.1)μg/mL、(321.1±68.3)ng/mL,均显著高于对照组的(190.2±58.4)μg/mL、(272.7±67.9)ng/mL(均P＜0.05)。治疗后第15天两组病人的GCS评分均显著高于治疗第1 天,APACHEⅡ以及SOFA评分均显著低于治疗第1天；而观察组病人的GCS评分为(12.8±3.4)分,显著高于对照组的(10.5±3.8)分,均差异有统计学意义(均P＜0.05)。 |
| 英文摘要: |
| Objective To study and analyzed the timely intervention therapy for gastrointestinal dysfunction after severe craniocerebral injury patients with the clinical curative effect. Methods From February 2015 to February 2017,0 cases of our hospital patients with gastrointestinal dysfunction after severe craniocerebral injury were selected as the research object,with random number table method and divided into observation group and control group,100 cases in each group.Patients in the control group admitted to hospital after 24—72 h weretreated with nasogastric tube start enteral nutrition therapy.The observation group of patients was treated with probiotics along with nasogastric tube.All the patients were treated for 15 d.The clinical curative effect,nutrition and biochemical indexes,GCS score,APACHEH ratings and SOFA score changes of the two groups respectively in 1 and 15 d were compared. Results The observation group of patients with clinical treatment of fine rate was 93.00% (93/100),significantly higher than that of control group 82.00% (82/100).The difference was statistically significant (P<0.05).15 d after treatment,patients after albumin,transferrin levels of the observation group was (234.5±60.1) μg/mL,(321.1±68.3) ng/mL,respectively,whichsignificantly higher than that of control group (190.2±58.4) μg/mL,(272.7±67.9) ng/mL,with statistically significant differences(all P<0.05).15 d after treatment,GCS score of patients in the two groups were significantly higher than that of 1 d after treatment.APACHEⅡ and SOFA score were significantly lower than 1 d treatment.And the GCS score for patients with observation group (12.8±3.4),significantly higher than that of control group (10.5±3.8),withstatistically significant differences(all P<0.05). Conclusion Clinical curative effect of nasogastric tube start enteral nutrition combination probiotics for the treatment of gastrointestinal dysfunction after severe craniocerebral injury is distinct,which can effectively improve the patients′ nutrition state,promote rehabilitation. |
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