| 宋艳斌,薛社亮,蔡高军.ABO血型与冠心病的相关性研究[J].安徽医药,2019,23(4):675-678. |
| ABO血型与冠心病的相关性研究 |
| Study on the relationship between ABO blood groups and coronary artery disease |
| 投稿时间：2017-04-22 |
| DOI： |
| 中文关键词: ABO血型系统 冠心病 危险因素 吸烟 脂蛋白类,HDL 脂蛋白类,IDL 高血压 |
| 英文关键词: ABO blood-group system Coronary disease Risk factors Smoking Lipoproteins,HDL Lipoproteins,IDL Hypertension |
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| 摘要点击次数: 1950 |
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| 中文摘要: |
| 目的 探索冠心病(CAD)与ABO血型的关系。方法 2012年12月至2014年12月在常州市武进人民医院住院的病人779例,分为CAD组663例和非CAD组116例。分析ABO血型与CAD的关系。结果 与非CAD组比较,CAD组年龄较大,男性、吸烟、高血压、糖尿病和低密度脂蛋白胆固醇(LDL-C)水平较高,高密度脂蛋白胆固醇(HDL-C)水平较低(均P<0.05)。两组间血型分布差异无统计学意义(χ2=7.691,P=0.053),女性人群中组间血型分布差异有统计学意义(χ2=10.006,P=0.019)。校正CAD的传统危险因素后,多因素logistic回归分析显示血型A、AB为CAD发病的独立危险因素(A:OR=2.168,AB:OR=2.726)。与非O血型比较,血型O(P=0.011)可显著降低CAD风险。结论 ABO血型与CAD的发病可能相关,且存在性别差异,A、AB血型是CAD发病的独立危险因素,O血型为保护性因素。 |
| 英文摘要: |
| Objective To investigate the association between ABO blood groups and coronary artery disease (CAD).Methods A total of 779 consecutive patients were enrolled,Changzhou Wujin People's Hospital from December 2012 and December 2014,including 663 cases in the CAD group and 116 cases in the non-CAD group.The relationship between ABO blood type and CAD was analyzed between the two groups.Results Compared with non-CAD group,subjects with CAD was older,with higher levels of men,smoking,hypertension,diabetes,lower density lipoprotein cholesterol (LDL-C) and higher density lipoprotein cholesterol (HDL-C) (all P＜0.05).There was no significant difference in blood group distribution between the two groups (χ2=7.691,P=0.053).There was significant difference in blood group distribution between the groups in blood group distribution (χ2=10.006,P=0.019).After adjusting for the traditional risk factors of CAD,multivariate logistic regression revealed that blood group Aand AB were independent risk factors for CAD (A:OR=2.168;AB:OR=2.726).Compared with non-O blood group,O blood group significantly reduced the risk of CAD (P=0.011).Conclusions The present study indicates that ABO blood groups may be related to the onset of CAD,and there are gender differences.The blood group Aand AB are independent risk factors for CAD,and Oblood group is a protective factor for CAD. |
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