| 葛国朝,张正君,李光耀.外周血中性粒细胞和淋巴细胞比值、营养指数及体质量指数与胃癌预后关系[J].安徽医药,2019,23(5):876-880. |
| 外周血中性粒细胞和淋巴细胞比值、营养指数及体质量指数与胃癌预后关系 |
| Study of the predictive relationship between gastric cancer and neutrophil-to-lymphocyte ratio,prognostic nutritional index and body mass index |
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| DOI：10.3969/j.issn.1009-6469.2019.05.009 |
| 中文关键词: 胃肿瘤 营养评价 中性粒细胞和淋巴细胞比值 体质量指数 危险因素 预后 |
| 英文关键词: Stomach neoplasms Nutrition assessment Neutrophil-lymphocyte ratio Body mass index Risk factors Prognosis |
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| 中文摘要: |
| 目的 探讨外周血中性粒细胞和淋巴细胞比值(NLR)、预后营养指数(PNI)、体质量指数(BMI)在胃癌根治术病人预后评价中的意义,为胃癌病人的临床诊治提供新思路。方法 回顾性分析芜湖市第二人民医院2009年1月至2012年7月143例胃癌病人的临床病理资料,分析NLR、PNI及BMI与临床病理特征之间的关系。采用Kaplan-Meier法绘制术后生存曲线和估计中位生存时间,用多重Cox等比例风险模型分析影响生存时间的因素。结果 NLR与病人性别相关(86.67%比71.43%,P＜0.05),PNI与病人神经侵犯状况有关(54.55%比35.23%,P＜0.05),BMI与病人年龄(77.63%比38.81%,P＜0.05)及CEA高低(68.09%比42.86%,P＜0.05)相关。单因素Kaplan-Meier分析表明NLR、PNI和BMI均与病人预后有关,但是多重Cox等比例风险模型分析表明仅PNI影响病人预后,低PNI病人死亡风险是高PNI病人死亡风险的1.751倍(95%CI:1.189～2.578)。结论 PNI是胃癌预后的独立因素,为临床胃癌病人的诊治提供了新的思路。 |
| 英文摘要: |
| Objective To investigate the predictive value of neutrophil-to-lymphocyte ratio (NLR),prognostic nutritional index (PNI),and body mass index (BMI) of gastric cancer (GC) after radical gastrectomy.Methods A total of 143 patients who had undergone curative gastrectomy for gastric cancer in the People’s Second Hospital of Wuhu from January 2009 to July 2012 were scheduled in our retrospective study.The association of NLR,PNI,and BMI with various clinicopathological characteristics and prognosis were evaluated.Results The NLR was associated with gender (86.67% vs.71.43%,P＜0.05),PNI was associated with perineural invasion (54.55% vs.35.23%,P＜0.05) and BMI was associated with age (77.63% vs.38.81%,P＜0.05) and the expression of CEA (68.09% vs.42.86%,P＜0.05).Univariate Kaplan-Meier analysis revealed that NLR,PNI and BMI were significant risk factors for prognosis.Multivariate analysis identified only PNI affected the prognosis in patients with gastic cancer in the Cox proportional hazard model.The death risk of patients with low PNI was 1.751 times of patients with high PNI (95%CI:1.189-2.578).Conclusion PNI was an independent prognostic factor for gastic cancer and provided a new idea for the diagnosis and treatment of patients with gastric cancer. |
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