| 陈磊,曹宏文,高人杰,等.周氏芪凌汤联合艾迪注射液治疗去势抵抗性前列腺癌的临床疗效研究[J].安徽医药,2019,23(5):1001-1005. |
| 周氏芪凌汤联合艾迪注射液治疗去势抵抗性前列腺癌的临床疗效研究 |
| Study on clinical effect of Zhou Qi Ling decoction combined with Aidi injection in the treatment of castration resistant prostate cancer |
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| DOI：10.3969/j.issn.1009-6469.2019.05.045 |
| 中文关键词: 前列腺肿瘤 睾丸切除术 中医治法 黄芪 冬凌草 人参 斑蝥 治疗结果 周氏芪凌汤 艾迪注射液 |
| 英文关键词: Prostatic neoplasms Orchiectomy Therapeutic methods (TCM) Astragalus membranaceus Rabdosia rubescens Ginseng Mylabris Treatment outcome Zhou Qi Ling decoction Aidi injection |
| 基金项目:上海中医药大学附属龙华医院第三批中青年名中医培养项目(RC-2017-01-14) |
| 作者 | 单位 | E-mail | | 陈磊 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 曹宏文 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 高人杰 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 郁超 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 何晓锋 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 赵友康 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 孙鹏 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 周智恒 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 龚华 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 王丹 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | | | 冯懿赓 | 上海中医药大学附属龙华医院泌尿外科,上海 200032 | fisher112@qq.com |
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| 中文摘要: |
| 目的 观察探析周氏芪凌汤、艾迪注射液联合疗法对去势抵抗性前列腺癌(CRPC)的临床疗效。方法 以2016年1月至2017年6月间上海中医药大学附属龙华医院收治的51例CRPC病人作为研究对象,双盲法随机分为对照组(25例)和联合组(26例)。均进行常规治疗,包括双侧睾丸切除及全雄激素阻断治疗。另外,对照组静脉滴注艾迪注射液50 mL,每日1次。联合组在对照组治疗基础上联合口服自拟“周氏芪凌汤”,随症加减。经过4个疗程(2个月)的治疗后,观察比较两组病人治疗前后的血清PSA、最大尿流速、KPS、VAS变化和不良反应情况及治疗有效率。结果 治疗后联合组前列腺体积显著缩小(体积缩小约10%),且与对照组相比,差异有统计学意义(P＜0.05);比较两组病人治疗前血清PSA、最大尿流速、KPS及VAS指标发现,差异无统计学意义(P＞0.05);但两组病人治疗后上述指标较治疗前均有所改善(P＜0.05),且联合组改善更为明显,差异有统计学意义(P＜0.05);对比两组病人的不良反应情况发现,除了恶心呕吐、贫血两组比较差异无统计学意义外,联合组在骨质疏松、骨髓抑制、去势综合征及下肢水肿上与对照组对比,均差异有统计学意义(P＜0.05);经过连续4个疗程的治疗后,对照组有效率和病情控制率分别为12.00%和48.00%,而联合组则分别为23.08%和57.69%,两组比较差异有统计学意义(P＜0.05)。结论 周氏芪凌汤联合艾迪注射液治疗CRPC可有效改善病人相关临床指标,提高疗效的同时还可减少并发症的发生,对病人的预后具有一定意义,临床值得推广运用。 |
| 英文摘要: |
| Objective To analyze the Zhou Qi Ling decoction,Aidi injection combined with prostate cancer therapy against potential (CRPC) curative effect.Methods 51 patients with CRPC from January 2016 to June 2017 in LongHua Hospital Shanghai University of Traditional Chinese Medicine as the research object,randomly divided into control group (25 cases) and combination group (in 26 cases).The control group Aidi injection treatment,combined treatment group with Zhou Qi Ling decoction,Aidi injection for treatment.After four courses of treatment (2 months) after treatment,the serum levels of PSA were observed before and after treatment in two groups were compared.The maximum flow rate,KPS and VAS The situation at the same time,the adverse reactions and the treatment of effective rate were compared.Results The prostate volume of the combined treatment group was reduced after treatment(about 10%),compared with control group,the-difference-was statistically-significant (P＜0.05).The two groups of patients before treatment,serum PSA,maximum urinary flow rate,KPS and VAS index was not statistically significant (P＞0.05),however the index of two groups after treatment than before treatment were significantly improved (P＜0.05),and the combined treatment group improved more significantly,with significant difference (P＜0.05).It was found that the adverse reaction of the two groups were compared,in addition to nausea and vomiting,anemia in two groups five significant differences,the combination group in osteoporosis,bone marrow suppression,castration syndrome and lower extremity edema were significantly better than the control group (P＜0.05).After 4 courses of treatment,the effective rate of the control group and the disease control rate were 12.00% and 48.00%,and the combined treatment group were 23.08% and 57.69%,there was significant difference between two groups (P＜0.05).Conclusion Zhou Qi Ling decoction combined with Aidi injection in the treatment of castration resistant prostate cancer can improve clinical indicators,the effect and reduce the complications can occur,which has certain significance for the prognosis of patients,worthy of promotion and application. |
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