| 梅海峰,梁宗敏,薛露,等.帕瑞昔布钠治疗脓毒症的疗效及对凝血功能的影响[J].安徽医药,2019,23(5):1021-1024. |
| 帕瑞昔布钠治疗脓毒症的疗效及对凝血功能的影响 |
| The efficacy of parecoxib-sodium in sepsis patients caused by burn and its impact on the coagulation function |
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| DOI：10.3969/j.issn.1009-6469.2019.05.050 |
| 中文关键词: 脓毒症 凝血酶时间 纤维蛋白原 嘧啶二聚物 炎症 T淋巴细胞 降钙素基因相关肽 肿瘤坏死因子类 CD4-CD8比值 帕瑞昔布钠 |
| 英文关键词: Sepsis Thrombin time Fibrinogen Pyrimidine dimers Inflammation T-Lymphocytes Calcitonin gene-related peptide Tumor necrosis factors CD4-CD8 ratio Parecoxib-sodium |
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| 中文摘要: |
| 目的 探讨帕瑞昔布钠在脓毒症病人中的疗效及对凝血功能的影响。方法 前瞻性收集2013年4月至2016年4月泰州市人民医院收治的脓毒症病人资料。入组病人采用随机数字表法分为两组:观察组(常规治疗+帕瑞昔布钠)和对照组(常规治疗),共纳入脓毒症病人92例,其中观察组和对照组分别为48例、44例。比较各组病人临床基线资料,预后、治疗前及治疗1周后的感染、炎症、T淋巴细胞亚群、凝血功能等相关指标。结果 治疗前两组病人的基线资料、感染、炎症、凝血功能、T淋巴细胞亚群等指标均差异无统计学意义(P＞0.05)。观察组病人的抗生素使用时间［(8.3±1.6)比(9.0±1.3) d］、ICU［(11.8±2.8)比(13.1±2.3) d］及总住院时间［(19.2±4.5)比(21.2±4.2) d］均低于对照组(P＜0.05)。而治疗1周后,观察组病人的降钙素原［PCT,(4.3±1.7)比(5.3±2.6) ng/L］、肿瘤坏死因子-α［TNF-α,(21.1±10.1)比(31.0±12.3)g/L］、白介素-6［IL-6,(110.1±30.1)比(146.3±38.4) ng/L)］、白介素-8［IL-8,(25.2±9.8)比(31.2±12.3) ng/L］、凝血酶时间［TT,(19.7±1.5)比(20.4±1.7)］、纤维蛋白原［FIB,(3.8±1.1)比(4.4±1.4) g/L］、D-二聚体［DD,(398.7±68.7)比(335.5±61.1) ng/mL］及[CD+8]%［(33.0±3.4)比(35.2±2.9)］比例水平显著低于对照组(P＜0.05),而[CD+4]%［(41.5±4.1)比(39.7±3.0)］及[CD+4]/[CD+8]比例［(1.61±0.58)比(1.35±0.44)］明显高于对照组(P＜0.05)。结论 帕瑞昔布钠可以有效的改善脓毒症病人的凝血、炎症及免疫功能。 |
| 英文摘要: |
| Objective Our retrospective study was aimed to observe the curative effect of parecoxib-sodium in sepsis patients and its impact on the coagulation function.Methods The clinical information of patients with sepsis received treatment at ICU in Jiangsu Taizhou People’s Hospital from April 2013 to April 2016 was prospectively collected.Patients using random number table method,observe group (traditional treatment + parecoxib-sodium) and control group (traditional treatment).The baseline information,prognosis,the infection,inflammation,T cell subsets and coagulation function before and after the treatment were compared.Results A total of 92 patients with sepsis caused by burn were finally analyzed,including 48 in observe group and 44 in control group.The indexes of infection,inflammation,T cell subsets and coagulation function before the treatment were with no significant difference between two groups (P＞0.05).The length of antibiotic use［(8.3±1.6) vs. (9.0±1.3) d］,ICU resistance time ［(11.8±2.8) vs. (13.1±2.3) d］ and hospitalization［(19.2±4.5) vs. (21.2±4.2) d］in observe group was significantly lower than control group (P＜0.05).The levels of PCT(4.3±1.7) vs. (5.3±2.6) ng/L,TNF-α(21.1±10.1) vs. (31.0±12.3) g/L,IL-6(110.1±30.1) vs. (146.3±38.4) ng/L,IL-8(25.2±9.8) vs. (31.2±12.3) ng/L,TT(19.7±1.5) vs. (20.4±1.7),FIB(3.8±1.1) vs. (4.4±1.4) g/L,DD(398.7±68.7) vs. (335.5±61.1) ng/mL and [CD+8]%(33.0±3.4) vs. (35.2±2.9) in observe group was significantly lower than control group at 1 week after the treatment(P＜0.05).Besides,the values of [CD+4]%(41.5±4.1) vs. (39.7±3.0)and [CD+4]/[CD+8](1.61±0.58) vs. (1.35±0.44)of patients in observe group were obviously higher than those in control group (P＜0.05).Conclusion Parecoxib-sodium can effectively improve the coagulation function,inflammatory reaction and immunologic function of T lymphocytes of patients with sepsis. |
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