| 李健,赵亮亮,叶立红,等.药物性胆管消失综合征2例[J].安徽医药,2019,23(5):1051-1053. |
| 药物性胆管消失综合征2例 |
| Two cases of drug-induced vanishing bile duct syndrom |
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| DOI：10.3969/j.issn.1009-6469.2019.05.058 |
| 中文关键词: 药物性肝损伤 腹水 肝肿大 黄疸 胆管炎 土霉素 阿莫西林 |
| 英文关键词: Drug-induced liver injury Ascites Hepatomegaly Jaundice Cholangitis Oxytetracycline Amoxicillin |
| 基金项目:河北省石家庄市科学技术研究与发展指导计划课题(151460903) |
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| 中文摘要: |
| 临床约10%的急性肝炎由药物性肝损伤(DILI)所引起。而药物或其代谢产物以胆管上皮为损伤靶点可诱发胆管消失综合征(VBDS)。VBDS在临床诊疗中时常被忽视或与其他胆管性疾病相混淆。因此,需要临床医生予以重视并加以鉴别。现报告2例VBDS典型病例。 |
| 英文摘要: |
| The incidence of drug-induced liver injury (DILI) is increasing year by year in China,and about 10% of the acute hepatitis is caused by DILI.Drug or its metabolites can induce vanishing bile duct syndrome (D-VBDS) with bile duct epithelium as the target of injury.VBDS are often neglected or confused with other bile duct diseases in clinical diagnosis and treatment.Therefore,it is necessary to arouse the attention of clinicians and identify them.The clinical manifestations of D-VBDS are classified into two types,major form and minor form,according to its clinical features,serum index and process.The histological pathological findings is based on the differences in the location and severity of bile duct. |
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