| 王宝安,杨爱成,黄泽.新诊断轻度活动的系统性红斑狼疮病人免疫及血管内皮功能的改变研究[J].安徽医药,2019,23(6):1109-1111. |
| 新诊断轻度活动的系统性红斑狼疮病人免疫及血管内皮功能的改变研究 |
| Changes of immune and vascular endothelial function in patients with newly diagnosed mild active systemic lupus erythematosus |
| 投稿时间：2017-07-23 |
| DOI： |
| 中文关键词: 系统性红斑狼疮 内皮功能 炎症 细胞因子 |
| 英文关键词: Systemic lupus erythematosus Endothelial function Inflammation Cytokine |
| 基金项目:江门市科技计划项目(江科2016〔100-10号〕) |
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| 中文摘要: |
| 目的 探讨新诊断轻度活动的系统性红斑狼疮病人免疫及血管内皮功能的改变及其关系。方法 选择2014年3月至2016年10月在江门市五邑中医院新诊断为轻度活动系统性红斑狼疮病人72例(SLE组),另选择同期进行健康体检者30例作为对照组,采用酶联免疫吸附实验法检测两组受检者外周血清中一氧化氮(NO)、内皮素1-(ET-1)、超敏C反应蛋白(hs-CRP)、γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)及白细胞介素4(IL-4)含量,同时利用超声检测肱动脉血流介导的内皮依赖性血管舒张功能(FMD),并与对照组相比。结果 SLE组病人中ET-1、hs-CRP、IFN-γ、TNF-α水平分别为(169.26±10.42)pg/mL、(20.17±4.37) mg/L、(12.83±2.36)ng/L、(36.67±5.17)pg/mL,均较对照组明显升高(均P＜0.05),NO[(23.62±3.68)μmol/L]、FMD[(7.62%±1.47%)]及IL-4[(7.76±2.31)pg/mL]水平下降(均P＜0.05),FMD与hs-CRP、IFN-γ、TNF-α呈显著负相关(r=-0.37,-0.43,-0.40；P＜0.05)。结论 新诊断的轻度活动的系统性红斑狼疮病人即存在内皮功能障碍,其发生与炎症密切相关,Th1和Th2两类细胞因子的失衡参与了系统性红斑狼疮所致的内皮功能障碍的发生。 |
| 英文摘要: |
| Objective To explore the changes of immune and vascular endothelial function in patients with newly diagnosed mild active systemic lupus erythematosus,and to investigate the correlation between immune and vascular endothelial function.Methods Seventy-two patients with newly diagnosed mild active systemic lupus erythematosus treated in The Wuyi Hospital of Traditional Chinese Medicine from March 2014 to October 2016 were enrolled in the study and the other 30 healthy subjects who received health checkup during the same period were selected as control group.Enzyme-linked immunosorbent assay (ELISA) was used to measure the contents of nitric oxide (NO),endothelin-1 (ET-1),hyper-sensitive C-reactive protein (hs-CRP),interferon-γ (IFN-γ),tumor necrosis factor (TNF-α),and interleukin-4 (IL-4) in peripheral serum of the two groups.The endothelium-dependent flow-mediated dilatation (FMD) mediated by brachial artery flow was determined with ultrasound and comparison was madebetween the two groups.Results The levels of ET-1 [(169.26±10.42) pg/mL],hs-CRP [(20.17±4.37) mg/L],IFN-γ [(12.83±2.36)ng/L],and TNF-α [(36.67±5.17) pg/mL] in the SLE group were significantly higher than those in the control group (all P<0.05);the levels of NO [(23.62±3.68) μmol/L],FMD [(7.62%±1.47%)],and IL-4 [(7.76±2.31) pg/mL] in the SLE group were lower than those in the control group (all P<0.05).FMD was negatively correlated with hs-CRP,IFN-γ,and TNF-α (r=-0.37,-0.43 and -0.40,respectively,P＜0.05).Conclusion Endothelial dysfunction is present in patients with newly diagnosed mild active systemic lupus erythematosus.Its occurrence is closely related to inflammation.The imbalance between the Th1 and Th2 is involved in the development of endothelial dysfunction caused by systemic lupus erythematosus. |
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