| 曹洁,梅晓冬.肺癌并发肺栓塞45例临床分析[J].安徽医药,2019,23(7):1354-1356. |
| 肺癌并发肺栓塞45例临床分析 |
| Clinical features in 45 patients of lung cancer copmlicated with pulmonary thromboembolism |
| 投稿时间：2017-11-16 |
| DOI： |
| 中文关键词: 肺肿瘤 肺栓塞 静脉血栓栓塞症 深静脉血栓形成 |
| 英文关键词: Lung cancer Pulmonary thromboembolism Venous thromboembolism Deep venous thrombosis |
| 基金项目:安徽省自然科学基金(1308085MH115) |
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| 摘要点击次数: 1936 |
| 全文下载次数: 523 |
| 中文摘要: |
| 目的 提高对肺癌(LC)并发肺栓塞(PTE)病人临床特征,危险因素及预后的认识。方法 对2012年1月至2017年6月中国科学技术大学附属第一医院45例LC合并PTE以及45例同期确诊LC的病人临床资料、实验室检查、治疗方法进行回顾性分析。结果 45例LC合并PTE病人临床表现主要有不明原因呼吸困难(34例 75.56%)。其中,肺腺癌 30例(66.67%),Ⅲ[KG-*3]～Ⅳ期LC 39例(86.67%),实验室检查,肺癌并发PTE者D-二聚体显著升高,与肺癌未合并PTE者比较,差异有统计学意义。多因素分析显示LC合并PTE危险因素包括病理类型(腺癌),TNM分期及D-二聚体。所有病人均接受低分子肝素抗凝治疗。结论 LC合并PTE临床表现以不明原因呼吸困难多见；多数病人为肺腺癌、且处于Ⅲ[KG-*3]～Ⅳ期,伴有高D-二聚体；此类病人预防性抗凝治疗是十分重要的。 |
| 英文摘要: |
| Objective To investigated the clinical characteristics,risk factors and treatment of patients with pulmonary thromboembolism(PTE) and lung cancer(LC).Methods From January 2012 to June 2007,Clinical characteristics,risk factors and laboratory examinations and treatment of 45 patients of LC with PTE were retrospectively analyzed in the First Affiliated Hospital of China University of Science and Technology.A total of 45 cases were used as control subjects.Results The patients with PTE and LC exhibited a high incidence of unexplained dyspnea(75.56%)Thirty cases of 45 patients of lung cancer with pulmonary thromboembolism were adenocarcinoma(66.67%),39 cases were stage Ⅲ-Ⅳ(86.67％).Laboratory examination showed the patients with both PTE and LC exhibited higher D-dimer than those with LC only(P＜0.05).D-Dimer＞500 ng/mL,adenocarcinoma,stage Ⅲ-Ⅳ were the risk factors of LC with PTE.All of them received low molecular heparin anticoagulation therapy.Conclusion The common pathological type in patients with both LC and PTE was adenocarcinoma.Most of the patients were advanced LC.The common clinical manifestations was unexplained dyspnea level of D-dimer.Anticoagulant therapy with low molecular weight heparin was important for the survival of those patients. |
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