| 李永春,李小芹,张迎辉.儿童肠道病毒性脑炎的临床特点及脑脊液病毒检测结果分析[J].安徽医药,2019,23(7):1369-1372. |
| 儿童肠道病毒性脑炎的临床特点及脑脊液病毒检测结果分析 |
| Clinical characteristics of children with enteroviral encephalitis and virus detection results of cerebrospinal fluid |
| 投稿时间：2018-01-15 |
| DOI： |
| 中文关键词: 脑炎,病毒性 肠道病毒属 儿童 临床特点 脑脊液 病毒抗体 |
| 英文关键词: Encephalitis,viral Children Enterovirus Clinical characteristics Cerebrospinal fluid Virus antibody |
| 基金项目:河南省医学科技攻关计划项目(201403251) |
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| 中文摘要: |
| 目的 探讨肠道病毒性脑炎(EVE)儿童的临床特点及脑脊液病毒检测结果。方法 回顾性分析河南省儿童医院2015年1月至2017年12月收治的216例EVE病儿病例资料。结果 临床特点:发热症状占69.44%,头痛占64.35%,呕吐占75.00%；6[KG-*3]～8月发病占39.35%,9[KG-*3]～11月占31.48%；白细胞(WBC)总数＞10×109/L占68.98%,C反应蛋白(CRP)升高占57.87%；脑电图轻中度异常检出率21.76%。脑脊液病毒检测:肠道病毒(EV)通用核酸检测阳性率55.56%,其中埃柯病毒30(ECHO30)型占79.17%；特异性IgM抗体阳性95例；不同年龄段、不同发病时间段病儿脑脊液EV通用核酸阳性检出率、特异性IgM抗体阳性检出率比较均差异有统计学意义(P均＜0.05)。预后:均治愈出院。结论 儿童EVE主要症状为发热、头痛及呕吐,好发于夏、秋季；脑脊液病毒检测以ECHO30为主且特异性IgM抗体检出率较高,经综合治疗后病儿预后良好。 |
| 英文摘要: |
| Objective To investigate the clinical characteristics of children with enteroviral encephalitis (EVE) and virus detection results of cerebrospinal fluid.Methods The data of 216 children with EVE who were admitted to the hospital from January 2015 to December 2017 were analyzed retrospectively.Results In terms of clinical characteristics,fever accounted for 69.44%,headache accounted for 64.35% and vomiting accounted for 75.00%.Onset in June-August accounted for 39.35%,and September-November accounted for 31.48%.The total white blood cell count (WBC)＞10×109/L accounted for 68.98%,and increased Creactive protein (CRP) accounted for 57.87%.The detection rate of mild and moderate abnormal electroencephalogram was 21.76%.The virus detection of cerebrospinal fluid showed that the general nucleic acid detection positive rate of enterovirus (EV) was 55.56%,and enteric cytopathic human orphan virus 30 (ECHO30) accounted for 79.17%.The specific IgM antibody was positive in 95 cases.There were significant differences in the general nucleic acid detection positive rate of EV and the positive rate of specific IgM antibody in cerebrospinal fluid between children of different age and onset time (P＜0.05).All children were cured and discharged from hospital.Conclusion The main symptoms of children with EVE are fever,headache and vomiting.The disease occurs frequently in summer and autumn.The virus detection of cerebrospinal fluid mainly includes ECHO30,and the detection rate of specific IgM antibody is high.After comprehensive treatment,the prognosis of children is good. |
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