| 张辉.血管内皮生长因子对老年骨折病人围手术期下肢深静脉血栓的影响[J].安徽医药,2019,23(7):1396-1399. |
| 血管内皮生长因子对老年骨折病人围手术期下肢深静脉血栓的影响 |
| The change trend and clinical value of vascular endothelial growth factor and thrombus map in patients with deep venous thrombosis in the perioperative period of fracture patients |
| 投稿时间：2018-01-15 |
| DOI： |
| 中文关键词: 血管内皮生长因子类 D-二聚体 深静脉血栓 纤维蛋白原 骨折 |
| 英文关键词: Vascular endothelial growth factor D-dimer Deep venous thrombosis Fibrinogen Fractures,bone |
| 基金项目:安徽省自然科学基金(No 1308085MH115) |
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| 中文摘要: |
| 目的 探讨老年骨折病人围手术期下肢深静脉血栓形成过程中血管内皮生长因子(VEGF)和血栓弹力图的变化趋势和临床价值。方法 选取2013年1月至2015年12月芜湖市中医医院老年骨折病人68例,均行手术治疗,根据在围手术期是否发生下肢深静脉血栓分为血栓组29例和非血栓组39例。分别于手术前、手术成功后1、5、10 d等时间点通过ELISA技术进行VEGF、D-二聚体、纤维蛋白原检测,并对全部病人在手术前后行血栓弹力图检测。结果 血栓组和非血栓组在手术后血清VEGF测量值 血栓组T1、T2、T3、T4值分别为(345.5±44.7)、(499.3±77.5)、(588.2±97.6)、(395.8±66.7)pg/mL,非血栓组分别为(363.1±51.3)、(441.6±83.2)、(493.5±84.3)、(364.3±59.3)pg/mL,均先升高后降低,术后各时间点血清VEGF测量值比较,血栓组均高于非血栓组(P＜0.05),血栓组病人术后血清VEGF含量上升更为显著,且峰值显著高于非血栓组。同时血栓组在不同时间点的VEGF测量值与相应的D-二聚体和血清纤维蛋白原含量呈强相关的关系(P＜0.05)；非血栓组在不同时间点的VEGF测量值与相应的D-二聚体和血清纤维蛋白原含量呈弱相关的关系(P＜0.05)。结论 老年骨折病人下肢深静脉血栓的形成过程中VEGF与血清D-二聚体、纤维蛋白原随着时间呈现一定变化规律,这些变化能够反映深部静脉血栓形成过程中血液凝聚状态和纤维蛋白溶解过程的变化,VEGF表达的升高对下肢深部静脉血栓的诊疗过程及其预后转归有一定的指导作用。 |
| 英文摘要: |
| Objective To explore the change trend and clinical value of vascular endothelial growth factor (VEGF) and thrombus map of patients with deep venous thrombosis (DVT) in the perioperative period.Methods 68 cases of elderly patients with fracture,were divided into 2 groups (DVT group,non-DVT group) According to whether had DVT perioperativly he serum VEGF,D-dimer and fibrinogen tested atpre and postsurgery.Results The level of VEGF was first rised and then decreased within DVT group(345.5±44.7),(499.3±77.5),(588.2±97.6),(395.8±66.7)pg/mL and non-DVT group(363.1±51.3),(441.6±83.2),(493.5±84.3),(364.3±59.3)pg/mL from T2 to T4 time point (P＜0.05).There was a strong positive correlation in DVT group between the level of VEGF and D-dimer /fibrinogen from T2 to T4 time point (P＜0.05).There was a weakly positive correlation in non-DVT group between the level of VEGF and D-dimer /fibrinogen from T2 to T4 time point (P＜0.05).Conclusion The changes of serum VEGF,D-dimer and fibrinogen in perioperative elderly fracture patients affected with DVT was dynamic correlated with each otherhe expression of VEGF may be more predictive and having prognostic value for acute deep venous thrombosis. |
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