| 李丽,张秀珊.乳腺多形性浸润性小叶癌的临床病理特征和预后[J].安徽医药,2019,23(8):1637-1640. |
| 乳腺多形性浸润性小叶癌的临床病理特征和预后 |
| Clinicopathologic characteristics and prognosis of invasive pleomorphic lobular carcinoma of the breast |
| 投稿时间：2018-05-07 |
| DOI： |
| 中文关键词: 乳腺肿瘤 浸润性小叶癌 原位癌 肿瘤侵润 Ki-67抗原 受体,表皮生长因子 病理学,分子 预后 |
| 英文关键词: Breast neoplasms Invasive lobular carcinoma Carcinoma in situ Neoplasm invasiveness Ki-67 antigen Receptor,epidermal growth factor Pathology,molecular Prognosis |
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| 摘要点击次数: 2319 |
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| 中文摘要: |
| 目的 研究乳腺多形性浸润性小叶癌(invasive pleomorphic lobular carcinoma,P-ILC)的临床病理特征及其预后。方法 选用2007年1月至2017年12月合肥市滨湖医院和安徽医科大学第一附属医院同期诊治的86例经典型浸润性小叶癌(classic invasive lobular carcinoma,C-ILC)和29例乳腺P-ILC病人的临床病理资料,回顾性分析研究P-ILC的临床病理特征及其预后因素。结果 与C-ILC相比,P-ILC病人TNM分期(χ2=3.902,P=0.048),肿瘤组织学分级(χ2=18.752,P<0.001),脉管浸润阳性率(27.6%比11.6%,χ2=4.183,P=0.044),Ki-67增殖指数(χ2=14.551,P=0.001)和人类表皮生长因子受体2(human epidermalgrowth factor receptor-2,HER-2)阳性率(χ2=9.135,P=0.015)均较高。单因素分析显示,P-ILC与C-ILC的无病生存率和总生存率均差异有统计学意义(P=0.047,P=0.038)。多因素分析显示淋巴结状态和TNM分期具有独立预后意义(P=0.038,P=0.031)。P-ILC与C-ILC的无病生存率和总生存率差异无统计学意义(P=0.532,P=0.481)。结论 与C-ILC相比,P-ILC病人TNM分期、肿瘤组织学分级、脉管浸润阳性率、Ki-67增殖指数和HER-2阳性率均较高。P-ILC具有较差的预后,需要更进一步的研究指导临床选择治疗策略。 |
| 英文摘要: |
| Objective To investigate the clinicopathological characteristics and the prognosis of invasive pleomorphic lobular carcinoma.Methods A retrospective analysis on 29 patients with invasive pleomorphic lobular carcinoma and 86 classical invasive lobular carcinoma admitted to Hefei Binhu Hospital and The First Affiliated Hospital of Anhui Medical University from January 2007 to December 2017 was performed in order to analysis the histological features and the clinical outcomes of invasive lobular carcinoma.Results Compared with C-ILC,the TNM staging (χ2=3.902,P=0.048),the tumor histological grade (χ2=18.752,P<0.001),the positive rate of vascular invasion (27.6% vs.11.6%,χ2=4.183,P=0.044),the Ki-67 proliferation index (χ2=14.551,P=0.001) and the human epidermal growth factor receptor-2 (HER-2) positive rate (χ2=9.135,P=0.015) were higher among P-ILC patients.A statistically significant difference in the outcome was observed at univariate analysis for patients with pleomorphic (P=0.047 for disease-free survival and P=0.038 for overall survival) versus patients with classical invasive lobular carcinoma.Multivariate analysis showed that lymph node status and staging had independent prognostic significance.The disease-free survival difference between the invasive pleomorphic lobular carcinoma and the classical invasive lobular carcinoma was not significant (P=0.532),and the overall survival rates were not statistically different between the two groups (P=0.481).Conclusion Compared with C-ILC,P-ILC patients has higher TNM stage,tumor histological grade,vascular infiltration positive rate,Ki-67 proliferation index and HER-2 positive rate.P-ILC has a poor prognosis.And further studies are certainly needed in order to clarify the clinical options and strategies. |
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