| 徐璟,孙国平.低剂量阿司匹林预防结直肠癌的研究进展[J].安徽医药,2019,23(9):1697-1700. |
| 低剂量阿司匹林预防结直肠癌的研究进展 |
| Advance in research on aspirin for prevention of colorectal cancer |
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| DOI：10.3969/j.issn.1009-6469.2019.09.001 |
| 中文关键词: 阿司匹林 结直肠癌 预防 低剂量 综述 |
| 英文关键词: Aspirin Colorectal cancer Prevention Low-dose Review |
| 基金项目:国家自然科学基金资助项目(81572430，81872047) |
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| 中文摘要: |
| 阿司匹林是一种水杨酸类非甾体抗炎药，临床上主要用于急性冠脉综合征(ACS)的一级预防。近年来，越来越多研究显示，阿司匹林能够降低多种恶性肿瘤的发生风险甚至显著减低病人的死亡率。美国预防服务工作组(USPSTF)发布一项建议，将低剂量阿司匹林列为成人结直肠癌等多种肿瘤的二级预防措施。该文旨在对阿司匹林预防结直肠癌及其作用机制的研究进行综述。 |
| 英文摘要: |
| Aspirin is a salicylic acid non-steroidal anti-inflammatory drug that is clinically used for primary prevention of acute coronary syndrome (ACS).In recent years，more and more studies have shown that long-term use of low-dose aspirin can reduce the risk of multiple malignant tumors and even significantly reduce the patient’s mortality.The US Preventive Services Task Force (USPSTF) have issued a proposal to initiate low-dose aspirin as one of the primary prevention measures for colorectal cancer.This article aims to review the recent studies to discuss the preventive effects of low-dose aspirin and its potential mechanism in colorectal cancer. |
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