| 黄歆,汪瑜,罗梅懿,等.雷奈酸锶对抗地塞米松诱导大鼠骨质疏松的作用[J].安徽医药,2019,23(9):1724-1728. |
| 雷奈酸锶对抗地塞米松诱导大鼠骨质疏松的作用 |
| Effect of strontium ranelate on dexamethasone-induced osteoporosis in rats |
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| DOI：10.3969/j.issn.1009-6469.2019.09.007 |
| 中文关键词: 雷奈酸锶 骨质疏松 大鼠 细胞增殖 骨形态学 |
| 英文关键词: Strontium ranelate Osteoporosis Rat Cell proliferation Bone morphology |
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| 中文摘要: |
| 目的 研究雷奈酸锶对地塞米松诱导骨质疏松大鼠的作用。方法 30只雌性SD大鼠采用随机数字表法分为5组:空白组，骨质疏松模型组，雷奈酸锶高、中、低剂量组。5周后进行骨形态学及血清指标检测，同时考察不同浓度雷奈酸锶对成骨细胞的体外增殖影响。结果 较模型组(38.00±2.36)μm，雷奈酸锶中、高剂量组的平均骨小梁厚度(48.50±4.05)μm、(52.00±4.44)μm明显升高(P＜0.05)，较模型组(189.90±19.27)μm，雷奈酸锶中、高剂量组的骨小梁间距(154.26±13.86)μm、(150.02±20.86)μm明显降低(P＜0.05)，表明雷奈酸锶的干预能明显改善骨显微结构指标。雷奈酸锶组高剂量较模型组大鼠血清白介素-6(IL-6)、骨性特异性磷酸酶(BALP)、抗酒石酸酸性磷酸酶(TRACP-5b)、Ⅰ型胶原C端肽(CTX-I)明显降低(P＜0.05)，骨钙素(OCN)、25羟基维生素D(25-HVD)明显升高(P＜0.05)。体外实验表明雷奈酸锶可促进成骨细胞增殖。结论 雷奈酸锶可促进成骨细胞增殖，改善骨形态及多项血清指标，对激素性骨质疏松有一定治疗作用。 |
| 英文摘要: |
| Objective To investigate the effect of strontium ranelate on dexamethasone-induced osteoporosis in rats.Methods Totally 30 female SD (Sprague-Dawley) rats were randomly divided into 5 groups:normal group，osteoporosis model group，high-dose group，medium-dose group and low-dose group.After 5 weeks，bone morphological and serum indices were detected，and the effects of different concentrations of strontium ranelate on the proliferation of osteoblasts in vitro were investigated.Results Compared with the model group(38.00±2.36)μm，the average trabecular bone thickness［(48.50±4.05)μm，(52.00±4.44)μm］ was significantly increased (P＜0.05).Compared with the model group(189.90±19.27)μm，the trabecular space［(154.26±13.86)μm，(150.02±20.86)μm］ was significantly decreased (P＜0.05) in the high/medium dose group which indicated that strontium ranelate could significantly improve the above indices to evaluate the bone microstructure.The levels of serum IL-6，BALP，5b (TRACP 5b) and CTX-I in the high dose group were significantly lower than those in the model group (P＜0.05)，and the osteocalcin and 25-hydroxyvitamin D were significantly increased (P＜0.05).In vitro experiment shows that strontium ranelate can promote osteoblast proliferation.Conclusion Strontium ranelate can promote the proliferation of osteoblasts and improve the bone morphology and a number of serum indices，which have definite treatment action on osteoporosis. |
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