| 王景媛,史亚军,黄维,等.复方龙脉宁磷脂复合物制备工艺及初步吸收评价[J].安徽医药,2019,23(9):1733-1736. |
| 复方龙脉宁磷脂复合物制备工艺及初步吸收评价 |
| The study on preparation of Fufang Longmaining phospholipid complex and preliminary absorption evaluation |
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| DOI：10.3969/j.issn.1009-6469.2019.09.009 |
| 中文关键词: 复方龙脉宁 磷脂复合物 制备工艺 外翻肠囊法 |
| 英文关键词: Fufang Longmaining Phospholipid complex Preparation technology Gut sac method |
| 基金项目:陕西省科技统筹创新工程计划项目(2012KTCQ03-13) |
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| 摘要点击次数: 1865 |
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| 中文摘要: |
| 目的 制备复方龙脉宁磷脂复合物并进行口服十二指肠体外吸收评价。方法 以复合率为评价指标，结合前期试验结果，采用正交法优选复方龙脉宁磷脂复合物的影响因素，包括药物浓度、复合时间、复合温度和药脂比；分别制备复方龙脉宁提取物与磷脂复合物，对二者采取外翻肠囊法测定改性前后在十二指肠段的吸收情况。结果 确定了以乙醇作为反应溶剂，提取物与大豆卵磷脂比例为1∶3，提取物的投料浓度为80-mg/mL，在40 ℃条件下复合12-h为最佳复合条件；采用磷脂复合物技术制备的复方龙脉宁磷脂复合物肠吸收较提取物显著增加。结论 磷脂复合物技术对于复方龙脉宁口服生物利用度的提高具有一定的适用性。 |
| 英文摘要: |
| Objective To study the preparation of Fufang Longmaining extract phospholipid complex and evaluate duodenum absorption characteristic.Methods The evaluation criterion was complex ratio. Combined with pretest results，the experiment inspect the significance influential factor such as phospholipids/drug，the drug concentration，the reaction time and temperature by orthogonal design. Everted gut sac method was used to evaluating the absorption situation of Fufang Longmaining extract and phospholipid complex.Results The ethyl alcohol was adoptedas reaction solvent. The screening process was as follows:the ratio of extract and phospholipid was 1∶3，extract concentration was 80-mg/mL，react time was 12 h at temperature40 ℃. The absorption of phospholipid complex was significantly increased.Conclusion Phospholipid complex technology has certain applicability in promoting the oral bioavailability of Fufang Longmaining. |
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