| 陈庆芸,刘运禅,石湘淋,等.气道高反应性637例[J].安徽医药,2019,23(9):1825-1827. |
| 气道高反应性637例 |
| Follow-up analysis of 637 cases of airway hyperresponsiveness |
| |
| DOI：10.3969/j.issn.1009-6469.2019.09.032 |
| 中文关键词: 气道高反应性 支气管激发试验 投药，吸入 糖皮质激素类 |
| 英文关键词: Airway hyperresponsiveness Bronchial provocation test Administration,inhalation Glucocorticoids |
| 基金项目:海南省医药卫生科研项目(1801032024A2001) |
|
| 摘要点击次数: 1826 |
| 全文下载次数: 583 |
| 中文摘要: |
| 目的 探讨气道高反应性病人的气道反应性分布特点及经过吸入糖皮质激素后气道反应性变化。方法 回顾性分析2017年1月至2018年9月海南省人民医院门诊637例初次检查支气管激发试验提示气道高反应性的病人，且在初次检查1个月后复查支气管激发试验。结果 轻度气道高反应性病人268例(42.07%)，中度气道高反应性病人249例(39.09%)，重度气道高反应性病人120例(18.84%)，组间比较，差异无统计学意义(χ2＝4.055，P＝0.132)。病人吸入糖皮质激素治疗的依从度中，轻度气道高反应性病人占20.15%，中度占50.60%，重度占71.67%，不同程度气道高反应性病人中依从性好者间比较，差异有统计学意义(χ2＝103.599，P＝0.000)。初次检查时轻度气道高反应性病人的PD20FEV1-组胺(1.376±0.493)μmol，治疗随访1个月后，升高到(2.321±0.312)μmol，差异有统计学意义。结论 气道高反应性病人吸入糖皮质激素治疗的依从性依气道反应性升高而升高。轻度气道高反应病人的气道反应性不稳定，急性气道感染是引起气道反应性变化的主要原因。 |
| 英文摘要: |
| Objective To investigate the distribution of airway reactivity in patients with airway hyperresponsiveness and the changes of airway reactivity after inhaling glucocorticoid.Methods Six hundred and thirty-seven patients with bronchial hyperresponsiveness indicated by initial examination of bronchial stimulation test in Outpatient of Department，Hainan Provincial People’s Hospital from January 2017 to September 2018 were selected and retrospectively analyzed.The bronchial provocation test was reexamined one month after the first examination.Results There were 268 cases (42.07%) with mild airway hyperreactivity，249 cases (39.09%) with moderate airway hyperreactivity and 120 cases (18.84%) with severe airway hyperreactivity，the difference was not statistically significant between the groups (χ2＝4.055，P＝0.132).The compliance of inhaled glucocorticoid therapy was 20.15% in mild，50.60% in moderate and 71.67% in severe，and the different was statistically significant between the groups (χ2＝103.599，P＝0.000).The changes of PD20 FEV1-histamine were observed after one month follow up.Only PD20 FEV1-histamine increased significantly in patients with mild airway hyperreactivity ［(1.376±0.493) μmol vs.(2.321±0.312)μmol］.Conclusion Compliance with inhaled glucocorticoid therapy in airway hyperresponsiveness patients is elevated with increased airway reactivity.The airway reactivity was unstable in patients with mild airway hyperactivity，and the change of airway reactivity caused by acute airway infection may be the main cause. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
