| 姚启凤,徐子涵,常文静,等.IgG4相关性淋巴结病的诊治与鉴别诊断要点[J].安徽医药,2019,23(11):2121-2124. |
| IgG4相关性淋巴结病的诊治与鉴别诊断要点 |
| Diagnosis，treatment and differential diagnosis of immunoglobulin G4?related lymphadenopathy |
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| DOI：10.3969/j.issn.1009?6469.2019.11.001 |
| 中文关键词: 自身免疫疾病 免疫球蛋白 G 浆细胞 IgG4相关性疾病 IgG4相关性淋巴结病 诊断 鉴别诊断 治疗 |
| 英文关键词: Autoimmune Diseases Immunoglobulin G Plasma Cells IgG4?related disease IgG4?related lymphadenopa? thy Diagnosis Differential diagnosis Treatment |
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| 中文摘要: |
| IgG4相关性疾病，包括各种以 IgG4开头命名的多种器官相关疾病，可出现单发或多发的淋巴结肿大，称为 IgG4相关性淋巴结病。 IgG4相关性淋巴结病分为 5个显微镜下亚型，它们都具有 IgG4免疫反应性浆细胞增多的特点。 IgG4相关性淋巴结病需要与多种疾病相鉴别，例如多中心 Castleman病( MCD)、反应性淋巴结病、 Rosai?Dorfman病、特发性结节内假瘤( IIPs)和炎性肌纤维母细胞瘤( IMT)、结节病、恶性肿瘤尤其是淋巴瘤等。因 IgG4相关疾病多数对糖皮质激素敏感，因此早期诊断 IgG4相关性淋巴结病至关重要。 |
| 英文摘要: |
| Immunoglobulin G4?related disease(IgG4?RD)encompasses diverse organ?related disorders named after IgG4，which may present with solitary or multifocal lymph node enlargement，and also known as IgG4?related lymphadenopathy(IgG4?RLAD).IgG4? RLAD has been subdivided into 5 microscopic subtypes，all of which demonstrate an excess of IgG4?immunoreactive plasma cellsin the inflammatory cell population.IgG4?RLAD needs to be distinguished from many diseases such as multicentricCastleman dis?ease(MCD)，reactive lymphadenopathy，RosaiDorfman syndrome，idiopathic intranodalpseudotumors(IIPs)and inflammatory myofi? broblastic tumor(IMT)，sarcoidosis，and malignancy，especially lymphoma.As IgG4?related diseases are mostly sensitive to glucocor? ticoids，early diagnosis and treatment of IgG4?associated lymphadenopathy are essential. |
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