| 胡庆刚,朱孝武.胸腹水总蛋白、单核细胞比例联合腺苷脱氨酶在结核性胸腹水中的诊断价值[J].安徽医药,2019,23(11):2183-2186. |
| 胸腹水总蛋白、单核细胞比例联合腺苷脱氨酶在结核性胸腹水中的诊断价值 |
| The diagnostic value of total protein，monocytes and adenosine deaminase in tuberculous pleuraloperitoneal fluids |
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| DOI：10.3969/j.issn.1009?6469.2019.11.016 |
| 中文关键词: 结核 胸水 /诊断 腹水 /诊断 腺苷脱氨酶 单核细胞 总蛋白 |
| 英文关键词: Tuberculosis Hydrothorax/diagnosis Ascites/diagnosis Adenosine deaminase Monocytes Total protein |
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| 中文摘要: |
| 目的探讨胸腹水总蛋白( P?TP)、单核细胞比例联合腺苷脱氨酶( P?ADA)在结核性胸腹水中的诊断价值。方法收集中国科学技术大学附属第一医院感染病院 106例胸腹水病人的临床资料，分成结核组 51例，非结核组 55例(病因包括低蛋白血症、心功能不全、恶性肿瘤、炎症感染和肝硬化)，进行胸腹水细胞数、单核细胞比例、 P?TP、P?ADA、葡萄糖( P?GLU)、乳酸脱氢酶( P?LDH)以及血清总蛋白( S?TP)、腺苷脱氨酶(S?ADA)、葡萄糖( S?GLU)测定。绘制 P?TP、单核细胞比例、 P?ADA的受试者工作特征曲线( ROC)计算灵敏度、特异度、阳性预测值和阴性预测值。结果结核组和非结核组的胸腹水细胞数、 P?TP、 P?ADA以及 SGLU差异有，统计学意义， P＜0.05。通过 ROC曲线分析， P?TP、单核细胞比例、 P?ADA单独检测曲线下面积分别为 0.891、0.598、0.901，诊断结核性胸腹水的灵敏度和特异度为 89.0%和 81.8%、86.0%和 33.0%、91.4%和 84.5%；P?TP、单核细胞比例联合 P?ADA检测诊断结核性胸腹水的灵敏度和特异度为 94.1%和 89.1%。结论 P?TP、P?ADA对结核性胸腹水的诊断具有一定参考价值， TP、单核细胞比例联合 ADA检测有助于结核性与非结核性胸腹水的鉴别。 |
| 英文摘要: |
| Objective To explore the diagnostic value of total protein(P?TP)and monocytes ratio combined with adenosine deami? nase(P?ADA)in tuberculous pleuraloperitoneal fluids.Methods Clinical data of 106 patients with pleuraloperitoneal fluids werecollected and divided into tuberculosis group with 51 cases and non tuberculosis group with 55 cases(The causes include hypoal? buminemia，cardiac insufficiency，malignant tumors，inflammatory infections and cirrhosis).The number of pleuraloperitoneal fluids cells，monocytes ratio，P?TP，P?ADA，glucose(P?GLU)，lactate dehydrogenase(P?LDH)serum total protein(STP)，adenosine de? aminase(S?ADA)and glucose(SGLU)were measured.The ROC curves of P?TP，monocyte，s ratio and P?ADA was drawn to calcu? late sensitivity，specificity，positive predictive value and negative predictive value.Results There were statistically significant dif? ferences in the number of pleuraloperitoneal fluids cells，P?TP，P?ADA and SGLU between the tuberculosis group and the non tuber? culosis group(P＜0.05).According to ROC curve analysis，the area under the curve of P?TP，monocytes ratio and P?ADA was 0.891，0.598 and 0.901,respectively.The sensitivity and specificity for the diagnosis of tuberculous pleuraloperitoneal fluids were 89.0% and 81.8%，86.0% and 33.0%，91.4% and 84.5%.The sensitivity and specificity of P?TP and monocytes ratio combined withADA in the diagnosis of tuberculous pleuraloperitoneal fluids were 94.1% and89.1%.Conclusion Total protein and ADA havecertain reference value for the diagnosis of tuberculous pleuraloperitoneal fluids.The combined detection of total protein，monocytesratio and ADA is helpful for the differential diagnosis of tuberculous and non?tuberculous pleuraloperitoneal fluids. |
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