| 何进伟,宋梅,邓家艳,等.辅助性 T细胞 22及其细胞因子水平在慢性乙型肝炎病人中的变化特点及临床意义[J].安徽医药,2019,23(11):2242-2244. |
| 辅助性 T细胞 22及其细胞因子水平在慢性乙型肝炎病人中的变化特点及临床意义 |
| Characteristics and clinical significance of helper T cell 22 and its cytokine levels in chronic hepatitis B(CHB) |
| |
| DOI：10.3969/j.issn.1009?6469.2019.11.032 |
| 中文关键词: 乙型肝炎，慢性 辅助性 T细胞 22 白细胞介素 ?22 丙氨酸氨基转移酶 |
| 英文关键词: Hepatitis B,chronic Helper T cell 22 Interleukin?22 Alanine aminotransferase |
| 基金项目:清远市科技计划项目( 170807211901012) |
|
| 摘要点击次数: 2338 |
| 全文下载次数: 1197 |
| 中文摘要: |
| 目的探讨慢性乙型肝炎( CHB)病人辅助性 T细胞 22(Th22)及其细胞因子水平及意义。方法选取 2017年 1月至 2018年 3月在连州市人民医院治疗的 CHB病人 40例(观察组)同时选取健康者 40例作为对照组，检测两组 Th22细胞、白细胞介素 ?22(IL?22)水平。结果观察组 Th22细胞、 IL?22水平分别为，(2.57±0.48)%和( 25.69±5.30)pg/mL，明显高于对照组( t＝ |
| 英文摘要: |
| Objective To investigate the level and significance of helper T cell 22(Th22)andthe cytokines in chronic hepatitis B(CHB).Methods From January 2017 to March 2018，40 cases of CHB patients were selected in Lianzhou People’s Hospital(ob? servation group)，and 40 healthy subjects were selected as control group，and two groups of Th22 cells and interleukin?22(IL?22) were detected.Results The level of Th22 cells and IL?22 in the observation group was(2.57±0.48)% and(25.69±5.30)pg/mL， which were significantly higher than that in the control group(P＜0.05).The levels of Th22 and IL?22 in patients with alanine ami? notransferase(ALT)＞5 times of normal value were(3.10±0.90)% and(30.02±5.22)pg/mL，which were significantly higher than those of 2?5 times normal values and＜2 times normal values(P＜0.05).There were no significant difference in Th22 cell and IL? 22 level in patients with different HBV DNA(P＞0.05).Th22 and IL?22 were positively correlated with ALT(r＝0.413 and 0.367， P＜0.05)，and Th22 was positively correlated with IL?22(r＝0.487，P＜0.05).Conclusion The levels of Th22 and IL?22 in CHB patients are significantly higher，with a certain correlation with ALT，which is worth further study. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
