| 曾旺,路明.α1?酸性糖蛋白检测在儿童川崎病中的价值[J].安徽医药,2019,23(11):2245-2247. |
| α1?酸性糖蛋白检测在儿童川崎病中的价值 |
| The value of determination of α1?acid glycoprotein in children’s Kawasaki disease |
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| DOI：10.3969/j.issn.1009?6469.2019.11.033 |
| 中文关键词: 川崎病 超敏 C反应蛋白 α1?酸性糖蛋白 前白蛋白 儿童 |
| 英文关键词: Kawasaki disease High?sensitivity C?reactive protein α1?acid glycoprotein Prealbumin Child |
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| 摘要点击次数: 2026 |
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| 中文摘要: |
| 目的探讨 α1?酸性糖蛋白( AAG)检测在儿童川崎病( KD)中的临床意义。方法选取 2014年 8月至 2017年 5月徐州医科大学附属医院住院的川崎病病人为 KD组( n＝51)，选取徐州医科大学附属医院同期年龄相仿的正常体检儿童及住院的感染性疾病病人分别作为健康对照组( n＝50)及感染组( n＝50)。采用速率散射比浊法检测各组的血清 AAG、血清超敏 C反应蛋白( hs?CRP)、和前白蛋白( PA)浓度。结果 ① KD组血清 AAG、hs?CRP浓度分别为( 239.43±61.57)mg/dL和( 92.22±59.25)mg/ L，与健康对照组［(83.35±17.00)mg/dL，1.86±0.84 mg/L］及感染组［(155.56±42.31)mg/dL，15.65±11.65 mg/L］比较均明显增高，差异有统计学意义( P＜0.05)，KD组血清 PA浓度( 0.11±0.05)g/L较对照组( 0.18±0.04)g/L及感染组( 0.15±0.04)g/L明显降低，差异有统计学意义( P＜0.05)； ②感染组血清 hs?CRP、AAG浓度高于健康对照组( P＜0.05)，血清 PA浓度低于健康对照组( P＜ 0.05)，差异有统计学意义。结论 AAG与 hs?CRP、PA一样与川崎病发生发展密切相关，可一定程度上协助川崎病的诊断。 |
| 英文摘要: |
| Objective To explore the diagnostic significances of α1?acid glycoprotein(AAG)in Kawasaki disease.Methods In a retrospective study，51 children with KD admitted in our hospital from 2014 August to 2017 May were enrolled，randomly selected age and sex?matched over the same period in hospital with infection disease in children as a infection group(n＝50)and physical examination children as control group(n＝50).Serum levels of AAG，hs?CRP and PA in each group were detected by rate scattering turbidimetry.Results ①Both of serum hs?CRP and AAG were significantly higher in KD group［( 239.43±61.57)mg/dL，(92.22± 59.25)mg/L］than those in control group［( 83.35±17.00)mg/dL，1.86±0.84 mg/L］and infection group［( 155.56±42.31)mg/dL，15.65±11.65 mg/L］( P＜0.05).PA in serum was significantly decreased in KD group(0.11±0.05)g/L compared with those in con? trol group(0.18±0.04)g/L and infection group(0.15±0.04)g/L(P＜0.05).② Both of serum hs?CRP and AAG were significantly higher in infection group than those in control group，PA in serum was significantly decreased in infection group compared with those in control group.Conclusion Same as hs?CRP and PA，AAG is closely related to the occurrence and development of Kawasa? ki disease，the determination of serum AAG has contribution to the diagnosis of Kawasaki disease. |
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