| 季艳霞,康振桥,赵艳争,等.阿帕替尼降低平滑肌肉瘤瘤体微血管密度的病例验证[J].安徽医药,2019,23(12):2501-2503. |
| 阿帕替尼降低平滑肌肉瘤瘤体微血管密度的病例验证 |
| Apatinib reduces microvascular density in leiomyosarcoma: a case report |
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| DOI：10.3969/j.issn.1009?6469.2019.12.043 |
| 中文关键词: 平滑肌肉瘤 阿帕替尼 微血管 内皮生长因子 结肠成像，计算机体层摄影 微血管密度 |
| 英文关键词: Leiomyosarcoma Apatinib Microvessels Endothelial growth factors Colonography,computed tomographic Microvessel density |
| 基金项目:北京医卫健康公益基金会“医学科学研究基金”项目(YWJKJJHKYJJ?F1169B) |
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| 中文摘要: |
| 目的观察阿帕替尼治疗前后瘤体微血管密度的变化。方法选择 2016年 5月邯郸市中心医院收治的 1例平滑肌肉瘤病人，第 1次根治手术组织行免疫组织化学染色，术后行 6周期化疗，腹部 CT提示复发后口服阿帕替尼 250 mg，每天 1次，治疗 5.5个月再次复发后行第 2次手术取病理，组织免疫组织化学 CD34染色，观察阿帕替尼治疗前后瘤体微血管密度的变化情况。结果阿帕替尼治疗平滑肌肉瘤，治疗后瘤体微血管密度显著降低，腹部 CT提示 4个月后腹腔肿瘤较前缩小。结论阿帕替尼可降低平滑肌肉瘤微血管密度，从而抑制肿瘤生长。 |
| 英文摘要: |
| Objective To observe changes in microvessel density after treatment with apatinib in leiomyosarcoma.Methods We received a patient with leiomyosarcoma who was treated in Handan Central Hospital in May 2016.The first radical operation wasperformed by immunohistochemical staining，and 6 cycles of chemotherapy were performed after surgery.After abdominal recur? rence，oral apatinib(250 mg，qd，po)was treated.Recurrence after 5.5 months，the second operation was performed for pathology， and tissue immunohistochemical staining for CD34 was performed to observe the changes of tumor microvessel density after treat?ment with apatinib.Results Apatinib was used to treat leiomyosarcoma，and the microvessel density of the tumor was significantly reduced after treatment，Abdominal CT indicated that abdominal lesions was smaller after 4 months.Conclusion Apatinib reduces microvascular density in leiomyosarcoma，and inhibits tumor growth. |
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