| 杜忠剑,冉思邈,张青萍,等.疏血通脉胶囊治疗急性脑梗死 60例临床疗效评价[J].安徽医药,2020,24(1):13-16. |
| 疏血通脉胶囊治疗急性脑梗死 60例临床疗效评价 |
| Clinical evaluation of shuxuetongmai capsule in treating acute cerebral infarction |
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| DOI：10.3969/j.issn.1009?6469.2020.01.004 |
| 中文关键词: 脑梗死 中草药 肺炎，吸入性 低蛋白血症 焦虑 疏血通脉胶囊 |
| 英文关键词: Brain infarction Drugs,Chinese herbal Pneumonia,aspiration Hypoproteinemia Anxiety Shuxue tongmai capsule |
| 基金项目:广西壮族自治区中医药管理局面上课题( GZPT1208) |
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| 中文摘要: |
| 目的明确疏血通脉胶囊对急性脑梗死的临床疗效。方法将 2015年至 2018年 6月广西中医药大学第一附属医院脑病科 180例诊断为急性脑梗死(痰瘀互结证)的病人采用随机数字表的方法分为治疗组、中药对照组和对照组，每组均为 60例，治疗组予疏血通脉胶囊治疗，空腹口服，一次 2粒( 1.0 g)；对照组予丁苯酞软胶囊治疗，空腹口服，一次 2粒( 0.2 g)；中药对照组予利脑心胶囊治疗，饭后口服，一次 4粒( 1.0 g)；均是一日三次， 4周为一疗程。疗程结束后观察三组病人 NIHSS(美国国立卫生研究院卒中量表)评分、 ADL(日常生活活动能力)评分、 SAS/SDS(焦虑 /抑郁自评量表)评分、及病后常见并发症发生情况。结果三组病人治疗前后 NIHSS评分、 ADL评分变化对比，三组病人治疗前 NIHSS评分、 ADL评分比较差异无统计学意义(P＞ 0.05)，治疗后均较前改善，差异有统计学意义( P＜0.05)，治疗组及中药对照组病人 NIHSS评分、 ADL评分改善情况较对照组好［NIHSS评分:(4.32±1.03)比( 4.54±1.20)比( 7.87±1.32)］［ADL评分:(78.32±6.25)比( 76.45±5.96)比( 57.54±5.43)］(P＜0.01)治疗组与中药对照组相比，治疗后 NIHSS评分、 ADL评分比较差异无统计学意义( P＞0.05)。三组病人均出现梗死后常见并症，治疗组和中药对照组梗死后出血、吸入性肺炎、低蛋白血症以及使用抗焦虑药物的人数均少于对照组( P＜0.05)，治疗组和中药对照组上述 4大指标对比则差异无统计学意义(P＞0.05)。三组病人中出现焦虑的病人中进行 SAS/SDS评分，三组病人在治疗后 SAS、SDS评分均下降( P＜0.05)其中治疗组与中药对照组病人评分比对照组低( P＜0.05)治疗组与中药对照组评分差异无统计学意义( P＞0.05)。治疗中药对照组在改善 NIHSS评分、 ADL评分、 SAS/SDS中作用优于对照组( P＜发，组和，评分，0.05)且两组在梗死后出血、吸入性肺炎、低蛋白血症、使用抗焦虑药物的人数以及抗焦虑效果均少于或优于对照组( P＜0.05)，研究组和中药对照组则在以上观察指标中差异无统计学意义( P＞0.05)。结论 疏血通脉胶囊对急性脑梗死症状改善具有良好疗效。 |
| 英文摘要: |
| Objective To clarify the clinical effect of shuxuetongmai Capsule on acute cerebral infarction.Methods 180 patients with acute cerebral infarction(phlegm and blood stasis syndrome)in from January 2015 to June 2018 were randomly divided into the treatment group，the Chinese medicine control group and the control group，with 60 patients in each.The treatment group was treated with shuxuetongmai capsule(0.5 g/capsule)，which was taken orally on an empty stomach，2 capsules(1g)at a time，3 times a day，4 weeks as a course of treatment.The control group was treated with conventional bupropion soft capsule treatment(0.1g/capsule)，take orally on an empty stomach，2 capsules(0.2 g)at a time，three times a day，four weeks as a course of treat? ment The control group of traditional Chinese medicine was treated with linanxin capsule(0.25 g/capsule)，take orally after meals， four capsules(1g)at a time，three times a day，four weeks as a course of treatment.After the treatment，NIHSS，ADL，SAS / SDS and common complications were observed.Results There was no significant difference in NIHSS score and ADL score before and af? ter treatment among the three groups(P＞0.05).However，after treatment，they were improved(P＜0.05).The improvement of NI?HSS score and ADL score in the treatment group and the traditional Chinese medicine control group was better than that in the con?trol group［NIHSS:(4.32±1.03)vs.(4.54±1.20)vs.(7.87±1.32)］［ADL:(78.32±6.25)vs.(76.45±5.96)vs.(57.54±5.43)］( P＜0.01) There was no significant difference in NIHSS score and ADL score between the two groups(P＞0.05).The common complications of the three groups.Post infarction hemorrhag，aspiration pneumonia and hypoproteinemia were compared.The patients in the treatmentgroup and the traditional Chinese medicine control group were less than those in the control group(P＜0.05).There was no signifi? cant difference between the treatment group and the traditional Chinese medicine control group(P＞0.05).The SAS / SDS scores of patients with anxiety in the three groups were lower than those in the control group(P＜0.05)，and there was no significant dif? ference between the two groups(P＞0.05).The treatment group and Chinese medicine control group were better than the control group in improving NIHSS score，ADL score and SAS / SDS score(P The difference(P＞0.05).Conclusion shuxuetongmai cap? sule has a good effect on improving the symptoms of acute cerebral infarction. |
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