| 张磊,蔡晓瑶,张莉,等.蟾皮提取物固体脂质纳米粒的冻干工艺研究[J].安徽医药,2020,24(1):78-82. |
| 蟾皮提取物固体脂质纳米粒的冻干工艺研究 |
| Study on the freeze?drying technology of solid lipid nanoparticles from toad skin extract |
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| DOI：10.3969/j.issn.1009?6469.2020.01.020 |
| 中文关键词: 华蟾蜍毒素/分离和提纯 纳米球 冷冻干燥法 药物稳定性 包封率 冻干保护剂 正交试验 |
| 英文关键词: Cinobufagin/isolation & purification Nanospheres Freeze drying Drug stability Drug entrapment efficiency Freeze?drying protective additive Orthogonal test |
| 基金项目:天津市自然科学基金( 17JCYBJC26700) |
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| 中文摘要: |
| 目的对蟾皮提取物固体脂质纳米粒冻干工艺进行考察。方法以外观、复溶性、颗粒形态为指标，筛选最佳的冻干保护剂和冻干工艺。结果选择乳糖、甘露醇、蔗糖、磷脂( 300 mg)比例为 1.5∶2∶1.5∶1作为混合保护剂，优化后的冻干工艺为-40 ℃下预冻 8h，-45 ℃下升华干燥 20 h、25 ℃下解析干燥 4h。结论通过优化保护剂和冻干工艺，制备的冻干固体脂质纳米粒外观饱满，复溶性好，稳定性得到显著提高。 |
| 英文摘要: |
| Objective To optimize solid lipid nanoparticles freeze?drying technology and prescription.Method The freeze?drying technology and types of freeze?drying protective additive were selected based on appearance，re?dissolution and microparticles mor? phous.Results The optimal freeze?drying protective additive was mixed by lactose，mannitol，sucrose，phospholipid(300mg)at 1.5 ∶2∶1.5∶1 ratio.After optimized，the freeze?drying process was prefreezing 8h under -40 ℃，sublimation?drying 20h under -45 ℃，de? sorption drying 4h under 25 ℃.Conclusion By optimizing the protective agent and lyophilization process，the freeze?drying solid lipid nanoparticles were prepared with plump appearance，a good re?dissolution and significantly improved stability. |
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