| 叶庆邦,蔡茵瑜,卓华钦.前列地尔联合阿托伐他汀钙治疗 2型糖尿病肾病合并颈动脉粥样硬化 40例[J].安徽医药,2020,24(2):398-401. |
| 前列地尔联合阿托伐他汀钙治疗 2型糖尿病肾病合并颈动脉粥样硬化 40例 |
| Effects of alprostadil and simvastatin on atherosclerotic plaque stabilityand hs?CRP，TNF?α and other inflammatory factors in patients with type 2 diabetic nephropathy complicated with carotid atherosclerosis |
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| DOI：10.3969/j.issn.1009?6469.2020.02.048 |
| 中文关键词: 糖尿病， 2型 动脉粥样硬化 颈动脉疾病 C反应蛋白质 肿瘤坏死因子 α 白细胞介素类 谷胱甘肽过氧化酶 前列地尔 阿托伐他汀钙 |
| 英文关键词: Diabetes mellitus,type 2 Atherosclerosis Carotid artery diseases C?reactive protein Tumor necrosis factor?al? pha Interleukins Glutathione peroxidase Alprostadil Simvastatin |
| 基金项目:东莞市社会科技发展项目( 201750715024134) |
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| 中文摘要: |
| 目的探讨前列地尔联合阿托伐他汀钙对 2型糖尿病肾病合并颈动脉粥样硬化病人的粥样斑块稳定性及超敏 C?反应蛋白( hs?CRP)、肿瘤坏死因子 α(TNF?α)等炎症因子的影响。方法选择 2016年 1月至 2018年 1月在东莞巿松山湖中心医院(东莞巿第三人民医院)收治的 2型糖尿病肾病合并颈动脉粥样硬化病人 80例。对照组病人以阿托伐他汀钙治疗，观察组在此基础上联合前列地尔治疗。观察两组病人的粥样斑块稳定性、炎症因子及氧化应激反应水平。结果治疗 2个月后两组斑块稳定性均高于治疗前( P＜0.05)。观察组治疗 2个月后的斑块稳定性高于对照组( P＜0.05)；观察组治疗 2个月后的 hs?CRP(2.04±0.62)μg/mL、TNF?α(22.1±2.3)ng/mL、白细胞介素 6(IL?6)(4.1±0.6)pg/mL、白细胞介素 8(IL?8)(6.4±0.7)pg/mL、丙二醛(MDA)(15.64±1.84)U/L、晚期氧化蛋白产物( AOPP)(41.03±5.43)μmol/L低于治疗前［hs?CRP(6.22±1.18)μg/mL、TNF?α(40.2±2.1)ng/mL、IL?6(8.2±2.1)pg/mL、IL?8(9.4±0.9)pg/mL、MDA(25.11±2.64)U/L、AOPP(75.17±6.34)μmol/L］及治疗 2个月后的对照组［hs?CRP(3.25±0.93)μg/mL、TNF?α(36.4±4.2)ng/mL、IL?6(7.4±0.9)pg/mL、IL?8(7.8±1.3)pg/mL、MDA(22.11±2.67)U/L、AOPP |
| 英文摘要: |
| Objective To analysis the effect Effects of alprostadil and simvastatin on atherosclerotic plaque stability and hs?CRP，TNF ?α and other inflammatory factors in patients with type 2 diabetic nephropathy complicated with carotid atherosclerosis Methods 80 cases of patients type 2 diabetic nephropathy with carotid atherosclerosis were treated from January 2016 to January 2018 in ThirdPeople’s Hospital of Dongguan.The control group was treated with simvastatin，and the observation group was combined with al? prostadil treatment.atherosclerotic plaque stability，inflammatory factors，and oxidative stress response in both groups were observed. Results Compared with the pre?treatment group，the plaque stability of the observation group and the control group was higher af? ter 2 months of treatment，and the difference was statistically significant(t＝6.493，5.084，6.383，5.421，4.551，5.943，P＜0.05).The plaque stability after 2 months of treatment was higher，the difference was statistically significant(t＝4.860，4.831，2.814，P＜0.05). The patients in the observation group were treated with hs?CRP［(2.04±0.62)μg/mL vs.(3.25±0.93)μg/mL］、 TNF?α［(22.1±2.3)ng/ mL vs.(36.4±4.2)ng/mL、IL?6［(4.1±0.6)pg/mL vs.(7.4±0.9)pg/mL］IL?8［(6.4±0.7)pg/mL vs.(7.8±1.3)pg/mL］、 MDA［(15.64±1.84) U/L vs.(22.11±2.67)U/L，AOPP［( 41.03±5.43)μmol/L vs.(61.54±6.6、7)μmol/L］were significantly lower，GSH?Px)［( 234.1±33.53) μg/mL vs.(192.4±17.63)μg/mL］，SOD［(19.34±3.32)μg/mL vs.(17.48±2.31)μg/mL］were significantly higher，the difference was statistically significant(P＜0.05).Conclusion Alprostadil combined with simvastatin can significantly improve the stability of ath?erosclerotic plaque in patients with type 2 diabetic nephropathy with carotid atherosclerosis，reduce inflammatory factors，oxidative stress response，and improve the efficacy of patients.It is worthy of clinical promotion. |
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