| 管锡芳,王文慧,孙宗琼.低剂量 CT灌注成像在进展期胃腺癌新辅助化疗疗效评价中的应用[J].安徽医药,2020,24(3):484-487. |
| 低剂量 CT灌注成像在进展期胃腺癌新辅助化疗疗效评价中的应用 |
| Application of low dose CT perfusion imaging in evaluation of neoadjuvant chemotherapy for advanced gastric adenocarcinoma |
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| DOI：10.3969/j.issn.1009?6469.2020.03.016 |
| 中文关键词: 胃肿瘤 体层摄影术，螺旋计算机 灌注成像 化学疗法，辅助 血流速度 血容量 |
| 英文关键词: Stomach neoplasms Tomography,spiral computed Perfusion imaging Chemotherapy,adjuvant Blood flow ve? locity Blood volume parameters |
| 基金项目:无锡市卫生计生委科研项目( MS201643) |
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| 中文摘要: |
| 目的探究低剂量 CT灌注成像的灌注参数值在进展期胃腺癌新辅助化疗疗效评价中的应用。方法选取江南大学附属医院 2017年 1—6月收治的进展期胃腺癌病人 46例作为研究对象。低剂量 CT灌注成像测取血流量及血容量，化疗结束 1周内手术切除肿瘤，评估术后病理疗效。对比有效组和无效组血流量、血容量在化疗前后的差异性，分析血流量、血容量减少率与病理疗效分级的相关性。结果有效组化疗后血流量为( 81.94±12.48)mL·100 g-1·min-1血容量为( 11.97±1.97)mL/100 g，均小于无效组的( 92.53±14.86)mL·100 g-1·min-1、(16.63±2.58)mL/100 g，差异有统计学意义，(t＝2.469、6.420，P＝0.018，＜ 0.001)；化疗后病理疗效有效组血流量、血容量减少率分别为( 14.96±2.58)%及( 42.49±9.57)%，均大于无效组的( 7.97±2.17)%、 |
| 英文摘要: |
| Objective To explore the application of perfusion parameters in low dose CT perfusion imaging in evaluating the effica?cy of neoadjuvant chemotherapy for advanced gastric adenocarcinoma.Methods 46 patients with advanced gastric adenocarcinomaadmitted to Affiliated Hospital of Jiangnan University from January 2017 to June 2017 were selected as the research subjects.Bloodflow parameters(BF)and blood volume parameters(BV)were measured by low?dose CT perfusion imaging.Tumors were resected within 1 weeks after the end of chemotherapy，and the pathological effects were evaluated.The difference of BF and BV between theeffective group and the ineffective group before and after chemotherapy was compared，and the correlation between the reduction rate of BF and BV and the grading of pathological efficacy was analyzed.Results The BF and BV of the effective group was(81.94±12.48)mL·100 g-1·min-1 and(11.97±1.97)mL/100 g，which were all smaller than the(92.53±14.86)mL·100 g-1·min-1 and(16.63±2.58)mL/100 g of the ineffective group，the difference was statistically significant(t＝2.469，6.420，P＝0.018，＜ 0.001).The reduction rates of BF and BV in the pathologically effective group after chemotherapy were(14.96±2.58)% and(42.49±9.57)%，which were greater than(7.97±2.17)% and(25.75±9.64)% of the ineffective group，and the differences were sta? tistically significant(t＝5.700，P＜0.001).Conclusion The reduction rate of BF and BV in low dose CT perfusion imaging can beused to evaluate the efficacy of chemotherapy in patients with advanced gastric adenocarcinoma，and is worthy of clinical promotion. |
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