| 姚彩霞,邢后彬,徐霁.ABCB1基因 G2677T/A多态性与血脂水平及他汀类药物降脂效应关系的 Meta分析[J].安徽医药,2020,24(3):551-556. |
| ABCB1基因 G2677T/A多态性与血脂水平及他汀类药物降脂效应关系的 Meta分析 |
| The role of ABCB1 G2677T/A polymorphisms in serum lipid levels and lipid?lowering response to statin treatment:a meta?analysis |
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| DOI：10.3969/j.issn.1009?6469.2020.03.033 |
| 中文关键词: 高脂血症 P糖蛋白 羟甲基戊二酰基 CoA还原酶抑制剂 多态性，单核苷酸 Meta分析 G2677T/A |
| 英文关键词: Hyperlipidemias P?glycoprotein Hydroxymethylglutaryl?CoA reductase inhibitors Polymorphism,single nucleotide Meta?analysis G2677T/A |
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| 中文摘要: |
| 目的评价 ABCB1基因 G2677T/A多态性与血脂水平及他汀类药物降脂效应的相关性。方法检索 Pubmed、Cochrane Library、CNKI、VIP和万方数据库。采用 MINORS量表对纳入的研究进行文献质量评价。用 RevMan 5.3软件进行统计分析。结果共纳入 10项独立研究，累计病人数 3 088例。 Meta分析结果显示携带 2677GG基因型与 non?GG基因型、 G non?G基因型或 Non?G non?G基因型人群之间的血脂水平( TC、LDL?C、HDL?C及 TG)差异无统计学意义，亦未发现这些不同组别人群之间他汀类药物降脂效应差异有统计学意义。结论基于研究结果，尚不能认为 ABCB1基因 G2677T/A多态性与血脂水平及他汀类药物降脂效应存在相关性。 |
| 英文摘要: |
| Objective To evaluate the associations of ABCB1 G2677T/A polymorphisms with serum lipid levels and lipid?loweringresponse to statin treatment.Methods The Pubmed，Cochrane Library，CNKI，VIP and Wanfang database were retrieved accordingto the uniform retrieval strategy.MINORS scale was adopted to evaluate the quality of included studies.Statistical analysis was per?formed with RevMan 5.3 software.Results A total of 10 independent studies were included with a total of 3 088 patients.The resultsof this meta?analysis showed that there was no statistically significant difference in serum lipid levels(TC，LDL?C，HDL?C and TG)be? tween patients with the 2677GG genotypes and those with the non?GG genotypes，G non?G genotypes or the Non?G non?G genotypes， nor was there statistically significant difference in lipid lowering efficacy of statin treatment between these groups. Conclusion The current meta?analysis suggested that ABCB1 G2677T/A polymorphism is not associated with serum lipid levels and lipid?lower?ing response to statin treatment. |
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