| 许婧,丁周志,刘娜娜,等.亚低温联合促红细胞生成素对新生儿缺氧缺血性脑病有效性及安全性 Meta分析[J].安徽医药,2020,24(5):849-854. |
| 亚低温联合促红细胞生成素对新生儿缺氧缺血性脑病有效性及安全性 Meta分析 |
| Validity and safety of hypothermia combined with EPO in the therapy of neonatal HIE:meta?analysis |
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| DOI：10.3969/j.issn.1009?6469.2020.05.001 |
| 中文关键词: 缺氧缺血，脑 S100蛋白质类 磷酸丙酮酸水合酶 婴儿，新生 Meta分析 亚低温 促红细胞生成素 |
| 英文关键词: Hypoxia ischemia,brain S100 Proteins Phosphopyruvate hydratase Infant,newborn Meta analysis Hypo thermia Erythropoietin |
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| 摘要点击次数: 2532 |
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| 中文摘要: |
| 目的系统评价亚低温联合促红细胞生成素( EPO)对治疗新生儿缺氧缺血性脑病( HIE)的有效性及安全性。方法检索 PubMed、Embase、the Cochrance Library、CBM、CNKI、万方数据库，收集随机对照试验，采用 Cochrane系统对文献偏倚进行评估，利用 Revman 5.3软件提取数据进行 Meta分析。结果最终纳入 12篇文献，文献方法学质量均不高。 Meta分析结果显示:亚低温联合 EPO与单独亚低温治疗比较，血清中枢神经特异蛋白( S100)及神经元特异性烯醇化酶( NSE)浓度均显著下降， S100浓度 MD＝-0.34，95%CI:-0.43~-0.25，P＜0.000 01；NSE浓度 SMD＝-1.74，95%CI:-1.96~-1.51，P＜0.000 01，均差异有统计学意义；联合治疗法较单独使用亚低温能提高 NABA评分， SMD＝1.64，95%CI:0.97~2.31，P＜0.000 01。在安全性评价方面，两者病死率及不良事件发生率均差异无统计学意义( P＞0.05)。结论亚低温联合 EPO在治疗新生儿 HIE方面，能降低血清 NSE和 S100蛋白的浓度，提高 NABA评分和神经功能水平，且具有较好的安全性。 |
| 英文摘要: |
| Objective To systematically evaluate the validity and safety of the mild hypothermia combined with erythropoietin(EPO)in the therapy of neonatal hypoxic ischemic encephalopathy(HIE).Methods PubMed，Embase，the Cochrance Library， CBM，CNKI，Wanfang database were searched and random controlled trials were collected.The bias of literature was evaluated byCochrane system.The data were extracted by Revman 5.3 software for meta?analysis.Results Finally，12 articles were included， though the quality of methodology was not very well.The results of meta?analysis showed:the therapy of the mild hypothermia com? bined with EPO compared with the mild hypothermia therapy alone:the concentration of S100 and NSE decreased significantly. S100 concentration MD＝-0.34，95%CI:-0.43?-0.25，P＜0.000 01；NSE concentration SMD＝-1.74，95%CI:-1.96?-1.51，P＜0.000 01.Compared with the mild hypothermia alone，the therapy of the mild hypothermia combined with EPO could increase the NABA score(SMD＝1.64，95%CI:0.97?2.31，P＜0.000 01).In terms of safety assessment，There was no significant difference in mortality and adverse reactions between the two groups(P＞0.05).Conclusion The therapy of the mild hypothermia combined with EPO in neonatal HIE can reduce the concentration of NSE and S100，increase the NABA score and the level of neurological function，and it has better safety meanwhile. |
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