| 张小聪,邓世昌,黄志石.术前血清肌腱蛋白?C水平与冠心病病人冠状动脉支架植入术后再狭窄的相关性分析[J].安徽医药,2020,24(5):927-930. |
| 术前血清肌腱蛋白?C水平与冠心病病人冠状动脉支架植入术后再狭窄的相关性分析 |
| Association between preoperative serum tenascin?C level and in?stent restenosis after PCI in patients with coronary heart disease |
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| DOI：10.3969/j.issn.1009?6469.2020.05.020 |
| 中文关键词: 冠状动脉再狭窄 血管内操作 /副作用 血清肌腱蛋白 ?C 药物洗脱支架 /副作用 冠心病 冠状动脉支架植入术 |
| 英文关键词: Coronary restenosis Endovascular procedures/adverse effects Serum tenascin?C Drug?eluting stents/ adverse effects Coronary heart disease Percutaneous coronary intervention |
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| 中文摘要: |
| 目的探讨术前血清肌腱蛋白 ?C水平与冠状动脉支架植入术( percutaneous coronary intervention，PCI)后再狭窄( in?stent restenosis，ISR)的相关性。方法选取 2016年 1月至 2018年 4月深圳市龙华区人民医院行 PCI术的冠心病病人 686例。检测术前血清肌腱蛋白 ?C水平，并估计其对冠心病病人 PCI术后 ISR的风险比。结果 12个月随访结束时，通过冠脉造影共发现 59例 ISR。基线数据比较发现， ISR组吸烟比例、糖尿病患病率、血尿酸、血清同型半胱氨酸、肌酐、植入支架数显著高于非 ISR组( P＜0.05)，血清高密度脂蛋白、植入支架平均直径显著低于非 ISR组( P＜0.05)。采用受试者工作特征曲线( Receiver oper? ating characteristic curve，ROC)显示血清肌腱蛋白 ?C对 PCI术后 ISR预测的最佳临界点为 62.3 ng/mL，AUC曲线下面积 0.84，灵敏度 85.4%，特异度 88.4%。多因素 logistic回归分析显示，血清肌腱蛋白 ?C水平升高( OR:1.84，95%CI:1.37~2.62)是冠心病病人 PCI术后发生 ISR的独立危险因素。结论血清肌腱蛋白?C水平升高可增加冠心病病人 PCI术后 ISR的发生风险。 |
| 英文摘要: |
| Objective To investigate the association between serum tenascin?C level and in?stent restenosis(IRS)after percutane? ous coronary intervention(PCI).Methods During January 2016 and April 2018，a total of 686 patients with coronary heart dis?ease who underwent PCI in our hospital were included.Preoperative serum tenascin?C were measured and the odds ratio of ISR af?ter PCI in patients with coronary heart disease estimated.Results At the end of 12?month follow?up，59 cases of ISR were found by coronary angiography.Baseline data showed that smoking rate，diabetes prevalence，serum uric acid，serum homocysteine，creati? nine and stent number in ISR group were significantly higher than those in non?ISR group(P＜0.05)，while serum high density li? poprotein and average diameter of stent were significantly lower than those in non?ISR group(P＜0.05).Receiver operating charac? teristic curve(ROC)showed that the optimal threshold of serum tenascin?C for predicting ISR after PCI was 62.3 ng/mL，the area under AUC curve was 0.84，the sensitivity was 85.4%，and the specificity was 88.4%.Multivariate Logistic regression analysis showed that elevated serum tenascin?C levels(OR:1.84，95%CI:1.37?2.62)were independent risk factors for ISR in patients with coronary heart disease after PCI.Conclusion Elevated serum tenascin?C levels may increase the risk of ISR in patients with coro? nary heart disease after PCI. |
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